Literature DB >> 8856868

DNA immunization.

D E Hassett1, J L Whitton.   

Abstract

Inoculation with plasmid DNA vectors encoding immunogenic proteins induces both humoral and cell-mediated immune responses, which often provide protective immunity. Although many questions regarding the mechanism, efficacy and safety of DNA immunization remain to be addressed, this approach may offer a safer and more cost-effective alternative to conventional vaccines.

Mesh：

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Year:  1996        PMID： 8856868     DOI： 10.1016/0966-842x(96)10048-2

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  27 in total

1.  Induction of antiviral antibodies by DNA immunization requires neither perforin-mediated nor CD8(+)-T-cell-mediated lysis of antigen-expressing cells.

Authors:  D E Hassett; J Zhang; J L Whitton
Journal:  J Virol       Date:  1999-09       Impact factor: 5.103

2.  Immune responses following neonatal DNA vaccination are long-lived, abundant, and qualitatively similar to those induced by conventional immunization.

Authors:  D E Hassett; J Zhang; M Slifka; J L Whitton
Journal:  J Virol       Date:  2000-03       Impact factor: 5.103

Review 3.  Chlamydial infection in sheep: immune control versus fetal pathology.

Authors:  G Entrican; D Buxton; D Longbottom
Journal:  J R Soc Med       Date:  2001-06       Impact factor: 5.344

4.  Contribution of C3d-P28 repeats to enhancement of immune responses against HBV-preS2/S induced by gene immunization.

Authors:  Li-Xin Wang; Wei Xu; Qing-Dong Guan; Yi-Wei Chu; Ying Wang; Si-Dong Xiong
Journal:  World J Gastroenterol       Date:  2004-07-15       Impact factor: 5.742

5.  DNA immunization: ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction.

Authors:  F Rodriguez; J Zhang; J L Whitton
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

6.  DNA vaccines expressing different forms of simian immunodeficiency virus antigens decrease viremia upon SIVmac251 challenge.

Authors:  Margherita Rosati; Agneta von Gegerfelt; Patricia Roth; Candido Alicea; Antonio Valentin; Marjorie Robert-Guroff; David Venzon; David C Montefiori; Phil Markham; Barbara K Felber; George N Pavlakis
Journal:  J Virol       Date:  2005-07       Impact factor: 5.103

7.  Neonatal DNA immunization with a plasmid encoding an internal viral protein is effective in the presence of maternal antibodies and protects against subsequent viral challenge.

Authors:  D E Hassett; J Zhang; J L Whitton
Journal:  J Virol       Date:  1997-10       Impact factor: 5.103

8.  Macrophage inflammatory protein-1alpha (MIP-1alpha) expression plasmid enhances DNA vaccine-induced immune response against HIV-1.

Authors:  Y Lu; K Q Xin; K Hamajima; T Tsuji; I Aoki; J Yang; S Sasaki; J Fukushima; T Yoshimura; S Toda; E Okada; K Okuda
Journal:  Clin Exp Immunol       Date:  1999-02       Impact factor: 4.330

Review 9.  Genetic vaccination against tuberculosis.

Authors:  D B Lowrie; C L Silva; R E Tascon
Journal:  Springer Semin Immunopathol       Date:  1997

10.  Comparison of intranasal and intramuscular immunization against human immunodeficiency virus type 1 with a DNA-monophosphoryl lipid A adjuvant vaccine.

Authors:  S Sasaki; K Hamajima; J Fukushima; A Ihata; N Ishii; I Gorai; F Hirahara; H Mohri; K Okuda
Journal:  Infect Immun       Date:  1998-02       Impact factor: 3.441
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