BACKGROUND: Various therapeutic modalities have been used for treating cutaneous leishmaniasis. Intralesional pentavalent antimonial injection is one of the effective therapeutic modalities. In this study, the efficacy of three different intralesional schedules with sodium stibogluconate have been investigated. METHODS: Ninety-six patients with 129 lesions were entered into the study, all with confirmed diagnosis of cutaneous leishmaniasis. The lesions were treated with three different schedules, including daily, alternate day, and weekly interlesional injections of sodium stibogluconate. The clinical response was then compared to arrive at the most effective schedule. RESULTS: The clinical responses (complete and partial cure) were 67%, 97%, and 91% for the daily, alternate-day, and weekly schedules, respectively. Lesions with either partial cure or failure of treatment were injected weekly with the same medication until complete cure had been achieved. The final overall success rate of complete cure was 99.2%. CONCLUSIONS: Alternate day or weekly intralesional treatment of cutaneous leishmaniasis with sodium stibogluconate are more effective than daily treatments.
BACKGROUND: Various therapeutic modalities have been used for treating cutaneous leishmaniasis. Intralesional pentavalent antimonial injection is one of the effective therapeutic modalities. In this study, the efficacy of three different intralesional schedules with sodium stibogluconate have been investigated. METHODS: Ninety-six patients with 129 lesions were entered into the study, all with confirmed diagnosis of cutaneous leishmaniasis. The lesions were treated with three different schedules, including daily, alternate day, and weekly interlesional injections of sodium stibogluconate. The clinical response was then compared to arrive at the most effective schedule. RESULTS: The clinical responses (complete and partial cure) were 67%, 97%, and 91% for the daily, alternate-day, and weekly schedules, respectively. Lesions with either partial cure or failure of treatment were injected weekly with the same medication until complete cure had been achieved. The final overall success rate of complete cure was 99.2%. CONCLUSIONS: Alternate day or weekly intralesional treatment of cutaneous leishmaniasis with sodium stibogluconate are more effective than daily treatments.
Authors: Erica de Camargo Ferreira E Vasconcellos; Maria Inês Fernandes Pimentel; Armando de Oliveira Schubach; Raquel de Vasconcellos Carvalhaes de Oliveira; Rilza Beatriz Azeredo-Coutinho; Fátima da Conceição Silva; Mariza de Matos Salgueiro; João Soares Moreira; Maria de Fátima Madeira; Cibele Baptista; Cláudia Maria Valete-Rosalino Journal: Am J Trop Med Hyg Date: 2012-08 Impact factor: 2.345
Authors: Abuzaid A Abuzaid; Abdalmohsin M Abdoon; Mohamed A Aldahan; Abdullah G Alzahrani; Raaft F Alhakeem; Abdullah M Asiri; Mohamed H Alzahrani; Ziad A Memish Journal: Vector Borne Zoonotic Dis Date: 2017-08-14 Impact factor: 2.133
Authors: Hafiz A Makeen; Mohammed A Buraik; Santhosh Joseph Menachery; Khalid M Alattas; Abdulkarim M Meraya Journal: Ann Dermatol Date: 2018-08-28 Impact factor: 1.444