| Literature DB >> 8852647 |
M Hegedüs1, L Petöcz, Z Budai, T Mezei.
Abstract
More than sixty 2-substituted-cycloalkanone-oxim-/2-hydroxy-3-dialkylamino/- propylethers were investigated on aconitine induced ventricular arrhythmia model in rats. According to the structure-activity relationships cyclohexanes containing diisopropylamine in the basic group were the most effective derivatives. Based on the highest per os activity and lowest toxicity EGIS-3966 (ED50 values 1.21 mg/kg iv. and 27.3 mg/kg per os) was selected for further development.Entities:
Mesh：
Substances：
Year: 1995 PMID： 8852647
Source DB: PubMed Journal: Acta Physiol Hung ISSN： 0231-424X