Bactericidal effect of sparfloxacin alone and in combination with amoxicillin against Streptococcus pneumoniae as determined by kill-kinetic studies.

Ten clinical isolates of Streptococcus pneumoniae (six intermediately penicillin-sensitive, one penicillin-resistant and three penicillin-sensitive strains) were studied by kill-kinetic experiments using sparfloxacin alone and in combination with amoxicillin. Equipotent doses of the antibiotics (1x, 2x and 4x the MIC) were used in the kill-kinetic studies. Sparfloxacin had a moderate bactericidal potential at 4x MIC after 5h and the combination with amoxicillin did not significantly increase its bactericidal activity. The clinical significance of these findings warrants further studies in vivo.