| Literature DB >> 88523 |
C F Schwender, B R Sunday, D J Herzig, E K Kusner, P R Schumann, D L Gawlak.
Abstract
A series of substituted 11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acids were prepared and evaluated as antiallergy agents. Several analogues were orally active. 2-Methyl-11-oxo-11H-pyrido[2,1-b]quinoazoline-8-carboxylic acid (6) was superior to cromolyn sodium and doxantrazole orally and intravenously in the rat PCA test and a rat allergic bronchospasm model.Entities:
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Year: 1979 PMID： 88523 DOI： 10.1021/jm00192a027
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446