Literature DB >> 885168

The prevention of alloxan-induced diabetes in mice by dimethyl sulfoxide.

R E Heikkila.   

Abstract

Dimethyl sulfoxide (DMSO, 7.3 g/kg) administered to mice prior to alloxan completely protected against the diabetogenic actions of 50 mg/kg alloxan. The same dose of DMSO provided a partial protection against 75 mg/kg alloxan. This protection against alloxan-induced diabetes is consistent with the scavenging of the hydroxyl radical by DMSO.

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Year:  1977        PMID： 885168     DOI： 10.1016/0014-2999(77)90106-6

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  18 in total

1.  Dimethyl sulfoxide and oxidative stress on cultures of human keratinocytes.

Authors:  Ivone da Silva Duarte; Alfredo Gragnani; Lydia Masako Ferreira
Journal:  Can J Plast Surg       Date:  2004

2.  Modification of chemically induced diabetes in rats by vitamin E. Supplementation minimizes and depletion enhances development of diabetes.

Authors:  A E Slonim; M L Surber; D L Page; R A Sharp; I M Burr
Journal:  J Clin Invest       Date:  1983-05       Impact factor: 14.808

3.  Influence of nicorandil on the pharmacodynamics and pharmacokinetics of gliclazide in rats and rabbits.

Authors:  S Satyanarayana; Eswar K Kilari
Journal:  Mol Cell Biochem       Date:  2006-05-19       Impact factor: 3.396

4.  Influence of atorvastatin on the pharmacodynamic and pharmacokinetic activity of repaglinide in rats and rabbits.

Authors:  Makula Chandra Sekhar; P Jaya Chandra Reddy
Journal:  Mol Cell Biochem       Date:  2012-01-07       Impact factor: 3.396

5.  Influence of selenium (antioxidant) on gliclazide induced hypoglycaemia/anti hyperglycaemia in normal/alloxan-induced diabetic rats.

Authors:  S Satyanarayana; J Rajad Sekhar; K Eswar Kumar; L Bacchus Shannika; Bettaiya Rajanna; Sharada Rajanna
Journal:  Mol Cell Biochem       Date:  2006-02       Impact factor: 3.396

6.  Superoxide dismutase, catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic islet cells in vitro.

Authors:  K Grankvist; S Marklund; J Sehlin; I B Täljedal
Journal:  Biochem J       Date:  1979-07-15       Impact factor: 3.857

7.  Dimethyl sulfoxide-induced differentiation does not alter tumorigenicity of neuroblastoma cells.

Authors:  Y L Danon; E Kaminsky
Journal:  J Neurooncol       Date:  1985       Impact factor: 4.130

8.  Alloxan-induced luminol luminescence as a tool for investigating mechanisms of radical-mediated diabetogenicity.

Authors:  K Grankvist
Journal:  Biochem J       Date:  1981-12-15       Impact factor: 3.857

9.  Enzymatic reduction of alloxan by thioredoxin and NADPH-thioredoxin reductase.

Authors:  A Holmgren; C Lyckeborg
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

10.  Influence of non-nucleoside reverse transcriptase inhibitors (efavirenz and nevirapine) on the pharmacodynamic activity of gliclazide in animal models.

Authors:  Sk Mastan; K Eswar Kumar
Journal:  Diabetol Metab Syndr       Date:  2009-10-09       Impact factor: 3.320
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