Literature DB >> 885138

Urea as a selective inhibitor of argininosuccinate lyase.

J Menyhárt, J Gróf.   

Abstract

The effect of urea on various ornithine cycle enzymes has been investigated. It was demonstrated that argininosuccinate lyase was the only ornithine cycle enzyme inhibited by urea in a competitive manner. Based on the data presented the possible role of urea in maintaining a physiological range of intracellular and extracellular urea concentration by controlling hepatic ureogenesis was discussed.

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Year:  1977        PMID： 885138     DOI： 10.1111/j.1432-1033.1977.tb11541.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  3 in total

1.  Inhibition of arginine synthesis by urea: a mechanism for arginine deficiency in renal failure which leads to increased hydroxyl radical generation.

Authors:  Kazumasa Aoyagi
Journal:  Mol Cell Biochem       Date:  2003-02       Impact factor: 3.396

2.  Effects of urea on K+ fluxes and cell volume in perfused rat liver.

Authors:  C Hallbrucker; S vom Dahl; M Ritter; F Lang; D Häussinger
Journal:  Pflugers Arch       Date:  1994-10       Impact factor: 3.657

3.  Capillary Electrophoresis Mass Spectrometry-Based Metabolomics of Plasma Samples from Healthy Subjects in a Cross-Sectional Japanese Population Study.

Authors:  Hiroyuki Yamamoto; Makoto Suzuki; Rira Matsuta; Kazunori Sasaki; Moon-Il Kang; Kenjiro Kami; Yota Tatara; Ken Itoh; Shigeyuki Nakaji
Journal:  Metabolites       Date:  2021-05-13
  3 in total

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