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Literature DB >> 8849693

Expression of photoreceptor cyclic nucleotide-gated cation channel alpha subunit (CNGCalpha) in the liver and skeletal muscle.

L Feng¹, I Subbaraya, N Yamamoto, W Baehr, N Kraus-Friedmann.

Abstract

Glucagon and beta-adrenergic agents increase cAMP levels and stimulate Ca2+ influx in liver cells. There is no consensus as to the mechanism by which these hormones stimulate the influx of Ca2+. Using mouse retinal rod CNGCalpha cDNA probes, we cloned rat liver and skeletal muscle, and human hepatic CNGCalpha subunit sequences showing 97-100% identity with the human rod channel. In order to assess channel activity, the effect of cyclic nucleotides on free intracellular Ca2+ levels of isolated hepatocytes was measured. Dibutyryl-cAMP was more effective in increasing free Ca2+ levels than dibutyryl-cGMP. These data indicate that the CNGCalpha subunit is expressed in both the liver and skeletal muscle possibly mediating hormonal effects on ion fluxes.

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Year: 1996 PMID： 8849693 DOI： 10.1016/0014-5793(96)01011-3

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

6 in total

1. Substituted cGMP analogs can act as selective agonists of the rod photoreceptor cGMP-gated cation channel.

Authors: J Y Wei; E D Cohen; H G Genieser; C J Barnstable
Journal: J Mol Neurosci Date: 1998-02 Impact factor: 3.444

2. Functional co-assembly among subunits of cyclic-nucleotide-activated, nonselective cation channels, and across species from nematode to human.

Authors: J T Finn; D Krautwurst; J E Schroeder; T Y Chen; R R Reed; K W Yau
Journal: Biophys J Date: 1998-03 Impact factor: 4.033

3. Somatostatin peptides produce multiple effects on gating properties of native cone photoreceptor cGMP-gated channels that depend on circadian phase and previous illumination.

Authors: Shih-Kuo Chen; Gladys Y-P Ko; Stuart E Dryer
Journal: J Neurosci Date: 2007-11-07 Impact factor: 6.167

Expression of photoreceptor cyclic nucleotide-gated cation channel alpha subunit (CNGCalpha) in the liver and skeletal muscle.

1. Substituted cGMP analogs can act as selective agonists of the rod photoreceptor cGMP-gated cation channel.

2. Functional co-assembly among subunits of cyclic-nucleotide-activated, nonselective cation channels, and across species from nematode to human.

3. Somatostatin peptides produce multiple effects on gating properties of native cone photoreceptor cGMP-gated channels that depend on circadian phase and previous illumination.

4. Movement of gating machinery during the activation of rod cyclic nucleotide-gated channels.

Review 5. Targeting Cyclic AMP Signalling in Hepatocellular Carcinoma.

Review 6. The Molecular Basis for Specificity at the Level of the Protein Kinase a Catalytic Subunit.