Literature DB >> 8848460

Neurosteroids block the memory-impairing effects of ethanol in mice.

C L Melchior1, R F Ritzmann.   

Abstract

Using a win-shift foraging paradigm to assess working memory in C57BL/6 mice, the memory-enhancing effect of low doses of the neurosteroids 5-pregnen-3 beta-ol-20-one [pregnenolone (PE)], 5-pregnen-3 beta-ol-20-one sulfate [pregnenolone sulfate (PS)], 5-androsten-3 beta-ol-17-one [dehydroepiandrosterone (DHEA)], and 5-androsten-3 beta-ol-17-one sulfate [dehydroepiandrosterone sulfate (DHEAS)] were demonstrated. The neurosteroids 5 beta-pregnan-3 alpha-ol-20-one [pregnanolone (PA)] and 5 beta-pregnan-3 beta-ol-20-one [epipregnanolone (EPI)] disrupted memory in this paradigm. PE, PS, DHEA, DHEAS, and PA were also capable of blocking the memory-impairing effect of 0.5 g/kg ethanol. EPI prevented PA from blocking the effect of ethanol. The influence of these compounds on memory and their interactions on this behavior are consistent with their actions on the GABAA system.

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Year:  1996        PMID： 8848460     DOI： 10.1016/0091-3057(95)00197-2

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  15 in total

1.  Dehydroepiandrosterone replacement in elderly individuals: still waiting for the proof of beneficial effects on mood or memory.

Authors:  O T Wolf; C Kirschbaum
Journal:  J Endocrinol Invest       Date:  1999-04       Impact factor: 4.256

Review 2.  Neurosteroids: endogenous role in the human brain and therapeutic potentials.

Authors:  Doodipala Samba Reddy
Journal:  Prog Brain Res       Date:  2010       Impact factor: 2.453

Review 3.  Wishing a dream came true: DHEA as a rejuvenating treatment?

Authors:  O T Wolf; C Kirschbaum
Journal:  J Endocrinol Invest       Date:  1998-02       Impact factor: 4.256

4.  A comparison of dehydroepiandrosterone and 7-keto dehydroepiandrosterone with other drugs that modulate ethanol intake in rats responding under a multiple schedule.

Authors:  Russell Joseph Amato; Mary Worrel Hulin; Peter John Winsauer
Journal:  Behav Pharmacol       Date:  2012-06       Impact factor: 2.293

5.  The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: distinct mechanisms?

Authors:  Y Akwa; N Ladurelle; D F Covey; E E Baulieu
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-20       Impact factor: 11.205

6.  The neurosteroid pregnenolone sulfate reduces learning deficits induced by scopolamine and has promnestic effects in mice performing an appetitive learning task.

Authors:  H Meziane; C Mathis; S M Paul; A Ungerer
Journal:  Psychopharmacology (Berl)       Date:  1996-08       Impact factor: 4.530

7.  Development and validation of an LC-MS/MS assay for the quantification of allopregnanolone and its progesterone-derived isomers, precursors, and cortisol/cortisone in pregnancy.

Authors:  G Mayne; E De Bloois; D Dabelea; U Christians
Journal:  Anal Bioanal Chem       Date:  2021-07-19       Impact factor: 4.142

Review 8.  Hormones and cognition: current concepts and issues in neuropsychology.

Authors:  D M Erlanger; K C Kutner; A R Jacobs
Journal:  Neuropsychol Rev       Date:  1999-12       Impact factor: 7.444

9.  Differential hypothalamic-pituitary-adrenal activation of the neuroactive steroids pregnenolone sulfate and deoxycorticosterone in healthy controls and alcohol-dependent subjects.

Authors:  Patrizia Porcu; Todd K O'Buckley; A Leslie Morrow; Bryon Adinoff
Journal:  Psychoneuroendocrinology       Date:  2007-12-21       Impact factor: 4.905

10.  The effect of dehydroepiandrosterone (DHEA) on recognition memory decision processes and discrimination in postmenopausal women.

Authors:  Elliot Hirshman; Ellen Wells; Margaret E Wierman; Benjamin Anderson; Andrew Butler; Meredith Senholzi; Julia Fisher
Journal:  Psychon Bull Rev       Date:  2003-03
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