Literature DB >> 8847528

A minimal and optimal cytotoxic T cell epitope within hepatitis C virus nucleoprotein.

H Kita1, K Hiroishi, T Moriyama, H Okamoto, T Kaneko, S Ohnishi, Y Yazaki, M Imawari.   

Abstract

Amino acid residues 81-100 of the hepatitis C virus (HCV) nucleoprotein contain a cytotoxic T cell epitope that is recognized by cytotoxic T lymphocytes (CTLs) in association with human leukocyte antigen B44. With panels of truncated and overlapping peptides, the minimal and optimal epitope recognized by CTLs was shown to be a 9-mer peptide (residues 88-96). The peptide can stimulate effectively CTLs that are able to recognize endogenously synthesized and processed HCV nucleoprotein.

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Year:  1995        PMID： 8847528     DOI： 10.1099/0022-1317-76-12-3189

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  9 in total

1.  Detection of diverse hepatitis C virus (HCV)-specific cytotoxic T lymphocytes in peripheral blood of infected persons by screening for responses to all translated proteins of HCV.

Authors:  D K Wong; D D Dudley; P B Dohrenwend; G M Lauer; R T Chung; D L Thomas; B D Walker
Journal:  J Virol       Date:  2001-02       Impact factor: 5.103

Review 2.  Cellular immune responses against hepatitis C virus: the evidence base 2002.

Authors:  S Ward; G Lauer; R Isba; B Walker; P Klenerman
Journal:  Clin Exp Immunol       Date:  2002-05       Impact factor: 4.330

3.  Identification of the immunodominant H-2K(k)-restricted cytotoxic T-cell epitope in the Borna disease virus nucleoprotein.

Authors:  K Schamel; P Staeheli; J Hausmann
Journal:  J Virol       Date:  2001-09       Impact factor: 5.103

4.  Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities.

Authors:  Georg M Lauer; Kei Ouchi; Raymond T Chung; Tam N Nguyen; Cheryl L Day; Deborah R Purkis; Markus Reiser; Arthur Y Kim; Michaela Lucas; Paul Klenerman; Bruce D Walker
Journal:  J Virol       Date:  2002-06       Impact factor: 5.103

Review 5.  Characteristics of the intrahepatic cytotoxic T lymphocyte response in chronic hepatitis C virus infection.

Authors:  M J Koziel; B D Walker
Journal:  Springer Semin Immunopathol       Date:  1997

6.  Comparative features of hepatitis C virus infection in humans and chimpanzees.

Authors:  C M Walker
Journal:  Springer Semin Immunopathol       Date:  1997

7.  The native form and maturation process of hepatitis C virus core protein.

Authors:  K Yasui; T Wakita; K Tsukiyama-Kohara; S I Funahashi; M Ichikawa; T Kajita; D Moradpour; J R Wands; M Kohara
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103

8.  Immune response of cytotoxic T lymphocytes and possibility of vaccine development for hepatitis C virus infection.

Authors:  Kazumasa Hiroishi; Junichi Eguchi; Shigeaki Ishii; Ayako Hiraide; Masashi Sakaki; Hiroyoshi Doi; Risa Omori; Michio Imawari
Journal:  J Biomed Biotechnol       Date:  2010-05-20

9.  Development and characterisation of recombinant hepatitis delta virus-like particles.

Authors:  S M Ward; T B Macnaughto; E J Gowans
Journal:  Virus Genes       Date:  2001       Impact factor: 2.332
  9 in total

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