BACKGROUND: Minor salivary gland cancer occurs infrequently and presents a diagnostic and therapeutic challenge. The purpose of this study was to determine prognostic factors for this disease. METHODS: The medical records of 95 patients diagnosed and treated at the University of Alabama at Birmingham over a 35-year period were reviewed. Information concerning patient, disease, and treatment characteristics was compiled for each case. Multivariate analysis was conducted using a rank regression procedure. RESULTS: State I or II cancer (p = .022), the absence of cervical lymph node metastases (p = .001), and surgical margins which were free of cancer (p < .001) were predictive of increased 4-year disease-free survival by multivariate analysis. CONCLUSION: Our findings emphasize the need for detection of early-stage disease combined with complete surgical extirpation of the cancer, which provide the patient with the best chance for locoregional control and long-term survival.
BACKGROUND: Minor salivary gland cancer occurs infrequently and presents a diagnostic and therapeutic challenge. The purpose of this study was to determine prognostic factors for this disease. METHODS: The medical records of 95 patients diagnosed and treated at the University of Alabama at Birmingham over a 35-year period were reviewed. Information concerning patient, disease, and treatment characteristics was compiled for each case. Multivariate analysis was conducted using a rank regression procedure. RESULTS: State I or II cancer (p = .022), the absence of cervical lymph node metastases (p = .001), and surgical margins which were free of cancer (p < .001) were predictive of increased 4-year disease-free survival by multivariate analysis. CONCLUSION: Our findings emphasize the need for detection of early-stage disease combined with complete surgical extirpation of the cancer, which provide the patient with the best chance for locoregional control and long-term survival.
Authors: Carlos Suárez; Leon Barnes; Carl E Silver; Juan P Rodrigo; Jatin P Shah; Asterios Triantafyllou; Alessandra Rinaldo; Antonio Cardesa; Karen T Pitman; Luiz P Kowalski; K Thomas Robbins; Henrik Hellquist; Jesus E Medina; Remco de Bree; Robert P Takes; Andrés Coca-Pelaz; Patrick J Bradley; Douglas R Gnepp; Afshin Teymoortash; Primož Strojan; William M Mendenhall; Jean Anderson Eloy; Justin A Bishop; Kenneth O Devaney; Lester D R Thompson; Marc Hamoir; Pieter J Slootweg; Vincent Vander Poorten; Michelle D Williams; Bruce M Wenig; Alena Skálová; Alfio Ferlito Journal: Auris Nasus Larynx Date: 2016-03-24 Impact factor: 1.863
Authors: Othman Bin-Alamer; Ali S Haider; Adhiraj Chaudhary; Kishore Balasubramanian; Tessa Breeding; Paolo Palmisciano; Maryam Haider; Aaron A Cohen-Gadol; Tarek Y El Ahmadieh; Kenny Yu Journal: Cancer Diagn Progn Date: 2022-09-03
Authors: Lucas R Salgado; Daniel E Spratt; Nadeem Riaz; Paul B Romesser; Suzanne Wolden; Shyam Rao; Christine Chin; Julian C Hong; Richard Wong; Nancy Y Lee Journal: Am J Clin Oncol Date: 2014-10 Impact factor: 2.339
Authors: Andrés Coca-Pelaz; Leon Barnes; Alessandra Rinaldo; Antonio Cardesa; Jatin P Shah; Juan P Rodrigo; Carlos Suárez; Jean Anderson Eloy; Justin A Bishop; Kenneth O Devaney; Lester D R Thompson; Bruce M Wenig; Primož Strojan; Marc Hamoir; Patrick J Bradley; Douglas R Gnepp; Carl E Silver; Pieter J Slootweg; Asterios Triantafyllou; Vincent Vander Poorten; Michelle D Williams; Alena Skálová; Henrik Hellquist; Afshin Teymoortash; Jesus E Medina; K Thomas Robbins; Karen T Pitman; Luiz P Kowalski; Remco de Bree; William M Mendenhall; Robert P Takes; Alfio Ferlito Journal: Adv Ther Date: 2016-03-19 Impact factor: 3.845
Authors: Terry A Day; John Deveikis; M Boyd Gillespie; John K Joe; Besim Ogretmen; J David Osguthorpe; Susan G Reed; Mary S Richardson; Michael Rossi; Ranjiv Saini; Anand K Sharma; Robert K Stuart Journal: Curr Treat Options Oncol Date: 2004-02