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Literature DB >> 8846164

The induction of p53 and WAF1/CIP1 in chronic lymphocytic leukemia cells treated with 2-chlorodeoxyadenosine.

R B Gartenhaus¹, P Wang, M Hoffman, D Janson, K R Rai.

Abstract

The treatment of chronic lymphocytic leukemia includes the use of alkylating agents, steroids, and more recently nucleoside analogues. While prior studies have described potential mechanisms of 2-chlorodeoxyadenosine cytotoxicity including the accumulation of DNA strand breaks and induction of apoptosis or programmed cell death, the expression of p53 and its downstream target WAF1/CIP1 have not been examined. In this report we describe the induction of p53 and WAF1/CIP1 in the apoptotic chronic lymphocytic leukemia cells after exposure to 2-chlorodeoxyadenosine.

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Year: 1996 PMID： 8846164 DOI： 10.1007/bf01575446

Source DB: PubMed Journal: J Mol Med (Berl) ISSN： 0946-2716 Impact factor: 4.599

22 in total

1. Mutations of the p53 gene in B-cell chronic lymphocytic leukemia: a report on 39 cases with cytogenetic analysis.

Authors: P Fenaux; C Preudhomme; J L Laï; I Quiquandon; P Jonveaux; M Vanrumbeke; C Sartiaux; P Morel; M H Loucheux-Lefebvre; F Bauters
Journal: Leukemia Date: 1992-04 Impact factor: 11.528

2. A randomized clinical trial of chlorambucil versus COP in stage B chronic lymphocytic leukemia. The French Cooperative Group on Chronic Lymphocytic Leukemia.

Authors:
Journal: Blood Date: 1990-04-01 Impact factor: 22.113

3. Effects of cytotoxicity of 2-chloro-2'-deoxyadenosine and 2-bromo-2'-deoxyadenosine on cell growth, clonogenicity, DNA synthesis, and cell cycle kinetics.

Authors: M C Huang; R A Ashmun; T L Avery; M Kuehl; R L Blakley
Journal: Cancer Res Date: 1986-05 Impact factor: 12.701

4. p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.

Authors: G Gaidano; P Ballerini; J Z Gong; G Inghirami; A Neri; E W Newcomb; I T Magrath; D M Knowles; R Dalla-Favera
Journal: Proc Natl Acad Sci U S A Date: 1991-06-15 Impact factor: 11.205

5. WAF1, a potential mediator of p53 tumor suppression.

Authors: W S el-Deiry; T Tokino; V E Velculescu; D B Levy; R Parsons; J M Trent; D Lin; W E Mercer; K W Kinzler; B Vogelstein
Journal: Cell Date: 1993-11-19 Impact factor: 41.582

6. Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells.

Authors: P Sarnow; Y S Ho; J Williams; A J Levine
Journal: Cell Date: 1982-02 Impact factor: 41.582

7. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.

Authors: S W Lowe; H E Ruley; T Jacks; D E Housman
Journal: Cell Date: 1993-09-24 Impact factor: 41.582

8. A single cycle of 2-chlorodeoxyadenosine results in complete remission in the majority of patients with hairy cell leukemia.

Authors: M S Tallman; D Hakimian; D Variakojis; D Koslow; G A Sisney; A W Rademaker; E Rose; K Kaul
Journal: Blood Date: 1992-11-01 Impact factor: 22.113

The induction of p53 and WAF1/CIP1 in chronic lymphocytic leukemia cells treated with 2-chlorodeoxyadenosine.

1. Mutations of the p53 gene in B-cell chronic lymphocytic leukemia: a report on 39 cases with cytogenetic analysis.

2. A randomized clinical trial of chlorambucil versus COP in stage B chronic lymphocytic leukemia. The French Cooperative Group on Chronic Lymphocytic Leukemia.

3. Effects of cytotoxicity of 2-chloro-2'-deoxyadenosine and 2-bromo-2'-deoxyadenosine on cell growth, clonogenicity, DNA synthesis, and cell cycle kinetics.

4. p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.

5. WAF1, a potential mediator of p53 tumor suppression.

6. Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells.

7. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.

8. A single cycle of 2-chlorodeoxyadenosine results in complete remission in the majority of patients with hairy cell leukemia.

Review 9. Advances in the biology and treatment of B-cell chronic lymphocytic leukemia.

10. Induction of WAF1/CIP1 by a p53-independent pathway.

1. Cyclin-dependent kinase inhibitors CIP1 (p21) and KIP1 (p27) in ovarian cancer.

2. A novel small molecule that selectively inhibits glioblastoma cells expressing EGFRvIII.

3. Key genes and drug delivery systems to improve the efficiency of chemotherapy.