PURPOSE: The purpose of this study was to examine the potential of 31P-MRS (MR spectroscopy) in the pre- and postoperative evaluation of patients referred for endarterectomy. MATERIAL AND METHODS: Nine patients with unilateral, hemodynamically significant stenosis in the region of the common carotid bifurcation were examined pre- and post-operatively with CT, SPECT (regional cerebral blood flow), transcranial Doppler, and duplex sonography, and they also underwent neuropsychologic investigation. Phosphorus-31 MRS of each hemisphere was performed before and 27-148 days after surgery. The relative concentrations of phosphomono- and -diesters, inorganic phosphate, phosphocreatine, and ATP were estimated. RESULTS: No definite changes in concentrations could be detected for any of the metabolites. CONCLUSION: The lack of changes was probably due to well-functioning collaterals and to the partial volume effect, whereby changes in a focal region are hidden when larger volumes are studied.
PURPOSE: The purpose of this study was to examine the potential of 31P-MRS (MR spectroscopy) in the pre- and postoperative evaluation of patients referred for endarterectomy. MATERIAL AND METHODS: Nine patients with unilateral, hemodynamically significant stenosis in the region of the common carotid bifurcation were examined pre- and post-operatively with CT, SPECT (regional cerebral blood flow), transcranial Doppler, and duplex sonography, and they also underwent neuropsychologic investigation. Phosphorus-31 MRS of each hemisphere was performed before and 27-148 days after surgery. The relative concentrations of phosphomono- and -diesters, inorganic phosphate, phosphocreatine, and ATP were estimated. RESULTS: No definite changes in concentrations could be detected for any of the metabolites. CONCLUSION: The lack of changes was probably due to well-functioning collaterals and to the partial volume effect, whereby changes in a focal region are hidden when larger volumes are studied.
Authors: E Hattingen; H Lanfermann; S Menon; T Neumann-Haefelin; R DuMesnil de Rochement; M Stamelou; G U Höglinger; J Magerkurth; U Pilatus Journal: MAGMA Date: 2008-10-15 Impact factor: 2.310