Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Potent block of volume-activated chloride currents in endothelial cells by the uncharged form of quinine and quinidine.

Literature DB >> 8842456

Potent block of volume-activated chloride currents in endothelial cells by the uncharged form of quinine and quinidine.

Abstract

1. The effects of quinine and quinidine on the volume-activated chloride current (ICl(vol)) in cultured endothelial cells from bovine pulmonary artery were studied by use of the whole-cell patch-clamp technique. 2. At pH 7.4 both quinine and quinidine induced a fast and reversible block of ICl(vol)) with Ki values of 20 +/- 4 microM and 30 +/- 10 microM, respectively. 3. The blocking efficiency of both drugs increased dramatically with increasing extracellular pH, indicating that the blockade is mediated by the uncharged form of quinine and quinidine. 4. These results suggest a hydrophobic interaction with high affinity between volume-activated chloride channels and uncharged quinine and quinidine within the membrane bilayer of endothelial cells.

Entities: Chemical Species

Mesh：

Substances：

Year: 1996 PMID： 8842456 PMCID： PMC1909854 DOI： 10.1111/j.1476-5381.1996.tb15616.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

19 in total

1. Alkalinization of acidic cellular compartments following cell swelling.

Authors: H Völkl; G L Busch; D Häussinger; F Lang
Journal: FEBS Lett Date: 1994-01-24 Impact factor: 4.124

2. Volume-sensitive chloride channels associated with human cervical carcinogenesis.

Authors: C Y Chou; M R Shen; S N Wu
Journal: Cancer Res Date: 1995-12-15 Impact factor: 12.701

3. Mechanosensitive Ca2+ transients in endothelial cells from human umbilical vein.

Authors: M Oike; G Droogmans; B Nilius
Journal: Proc Natl Acad Sci U S A Date: 1994-04-12 Impact factor: 11.205

4. Tamoxifen enhances cell death in implanted MCF7 breast cancer by inhibiting endothelium growth.

Authors: E F Haran; A F Maretzek; I Goldberg; A Horowitz; H Degani
Journal: Cancer Res Date: 1994-11-01 Impact factor: 12.701

5. Volume regulation in a toad epithelial cell line: role of coactivation of K+ and Cl- channels.

Authors: B Nilius; J Sehrer; P De Smet; W Van Driessche; G Droogmans
Journal: J Physiol Date: 1995-09-01 Impact factor: 5.182

6. Volume-activated Cl- currents in different mammalian non-excitable cell types.

Authors: B Nilius; J Sehrer; F Viana; C De Greef; L Raeymaekers; J Eggermont; G Droogmans
Journal: Pflugers Arch Date: 1994-10 Impact factor: 3.657

7. Inhibition of volume-activated chloride currents in endothelial cells by chromones.

Authors: S Heinke; G Szücs; A Norris; G Droogmans; B Nilius
Journal: Br J Pharmacol Date: 1995-08 Impact factor: 8.739

8. Volume-activated chloride currents in pancreatic duct cells.

Authors: B Verdon; J P Winpenny; K J Whitfield; B E Argent; M A Gray
Journal: J Membr Biol Date: 1995-09 Impact factor: 1.843

9. Permeation properties and modulation of volume-activated Cl(-)-currents in human endothelial cells.

Authors: B Nilius; J Sehrer; G Droogmans
Journal: Br J Pharmacol Date: 1994-08 Impact factor: 8.739

10. Small-conductance chloride channels in human peripheral T lymphocytes.

Authors: P A Schumacher; G Sakellaropoulos; D J Phipps; L C Schlichter
Journal: J Membr Biol Date: 1995-06 Impact factor: 1.843

11 in total

1. Quinine blocks specific gap junction channel subtypes.

Authors: M Srinivas; M G Hopperstad; D C Spray
Journal: Proc Natl Acad Sci U S A Date: 2001-09-04 Impact factor: 11.205

2. Regulation of a swelling-activated chloride current in bovine endothelium by protein tyrosine phosphorylation and G proteins.

Authors: T Voets; V Manolopoulos; J Eggermont; C Ellory; G Droogmans; B Nilius
Journal: J Physiol Date: 1998-01-15 Impact factor: 5.182

3. Activation of volume-regulated chloride currents by reduction of intracellular ionic strength in bovine endothelial cells.

Authors: B Nilius; J Prenen; T Voets; J Eggermont; G Droogmans
Journal: J Physiol Date: 1998-01-15 Impact factor: 5.182

Potent block of volume-activated chloride currents in endothelial cells by the uncharged form of quinine and quinidine.

1. Alkalinization of acidic cellular compartments following cell swelling.

2. Volume-sensitive chloride channels associated with human cervical carcinogenesis.

3. Mechanosensitive Ca2+ transients in endothelial cells from human umbilical vein.

4. Tamoxifen enhances cell death in implanted MCF7 breast cancer by inhibiting endothelium growth.

5. Volume regulation in a toad epithelial cell line: role of coactivation of K+ and Cl- channels.

6. Volume-activated Cl- currents in different mammalian non-excitable cell types.

7. Inhibition of volume-activated chloride currents in endothelial cells by chromones.

8. Volume-activated chloride currents in pancreatic duct cells.

9. Permeation properties and modulation of volume-activated Cl(-)-currents in human endothelial cells.

10. Small-conductance chloride channels in human peripheral T lymphocytes.

1. Quinine blocks specific gap junction channel subtypes.

2. Regulation of a swelling-activated chloride current in bovine endothelium by protein tyrosine phosphorylation and G proteins.

3. Activation of volume-regulated chloride currents by reduction of intracellular ionic strength in bovine endothelial cells.

4. Block by fluoxetine of volume-regulated anion channels.

5. Pharmacological modulation of monovalent cation currents through the epithelial Ca2+ channel ECaC1.

6. Membrane currents and the resting membrane potential in cultured bovine pulmonary artery endothelial cells.

7. Inhibition of the endogenous volume-regulated anion channel (VRAC) in HEK293 cells by acidic di-aryl-ureas.

8. An Exploration of Charge Compensating Ion Channels across the Phagocytic Vacuole of Neutrophils.

9. The LRRC8A Mediated "Swell Activated" Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils.

10. Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine.