| Literature DB >> 8841588 |
H Yamakawa1, K Hosono, T Ishibashi, K Takai, H Takaku.
Abstract
We have designed a new type of antisense oligodeoxyribonucleotide. These oligonucleotides form two hairpin loop structures with RNA-DNA base pairs (sense (RNA) and antisense (DNA)) in the double helical stem. The nicked and circular dumbbell RNA/DNA chimeric oligonucleotides are molecules, with or without free ends, that are more resistant to exonuclease attack. Of particular interest, antisense DNA is liberated by RNase H treatment of the dumbbell RNA/DNA chimeric oligonucleotides.Entities:
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Year: 1995 PMID： 8841588
Source DB: PubMed Journal: Nucleic Acids Symp Ser ISSN： 0261-3166