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Literature DB >> 884018

Dual effect of disopyramide on atrial and atrioventricular conduction and refractory periods.

Abstract

Disopyramide has been shown in conditions of cholinergic blockade to have a depressant effect upon sinus node automaticity and the atrial refractoriness. It also prolongs atrioventricular conduction and increases atrioventricular refractoriness. These effects may often be masked in vivo by the anticholinergic effects of the drug.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1977 PMID： 884018 PMCID： PMC483295 DOI： 10.1136/hrt.39.6.657

Source DB: PubMed Journal: Br Heart J ISSN： 0007-0769

11 in total

1. The pharmacokinetics of disopyramide following myocardial infarction with special reference to oral and intravenous dose regimens.

Authors: J W Ward; G R Kinghorn
Journal: J Int Med Res Date: 1976 Impact factor: 1.671

2. Acute termination of cardiac arrhythmias with intravenous disopyramide.

Authors: H F Mizgala; P R Huvelle
Journal: J Int Med Res Date: 1976 Impact factor: 1.671

3. The effect of disopyramide on in vivo measurement of monophasic action potential in canine heart muscle.

Authors: I R Edwards; J F Martin; J W Ward
Journal: J Int Med Res Date: 1976 Impact factor: 1.671

Review 4. Classification of antidysrhythmic drugs.

Authors: E M Vaughan Williams
Journal: Pharmacol Ther B Date: 1975

5. Class 3 antiarrhythmic action in man. Observations from monophasic action potential recordings and amiodarone treatment.

Authors: S B Olsson; L Brorson; E Varnauskas
Journal: Br Heart J Date: 1973-12

6. Effects of disopyramide on electrophysiological and mechanical properties of the heart.

Authors: B K Yeh; P K Sung; B J Scherlag
Journal: J Pharm Sci Date: 1973-12 Impact factor: 3.534

7. Electrophysiological evaluation of disopyramide in man.

Authors: M E Josephson; A R Caracta; S H Lau; J J Gallagher; A N Damato
Journal: Am Heart J Date: 1973-12 Impact factor: 4.749

8. Electrophysiologic effects of the antiarrhythmic agent disopyramide phosphate.

Authors: B Befeler; A Castellanos; D E Wells; M C Vagueiro; B K Yeh
Journal: Am J Cardiol Date: 1975-02 Impact factor: 2.778

9. Effects of disopyramide on electrophysiological properties of specialized conduction system in man and on accessory atrioventricular pathway in Wolff-Parkinson-White syndrome.

Authors: R A Spurrell; C W Thorburn; J Camm; E Sowton; D C Deuchar
Journal: Br Heart J Date: 1975-08

10. A COMPARISON OF THE ANTIFIBRILLATORY ACTIONS AND EFFECTS ON INTRACELLULAR CARDIAC POTENTIALS OF PRONETHALOL, DISOPYRAMIDE AND QUINIDINE.

Authors: A SEKIYA; E M VAUGHANWILLIAMS
Journal: Br J Pharmacol Chemother Date: 1963-12

18 in total

Review 1. Antiarrhythmic drug classifications. A critical appraisal of their history, present status, and clinical relevance.

Authors: S Nattel
Journal: Drugs Date: 1991-05 Impact factor: 9.546

2. Disopyramide and warfarin interaction.

Authors: E Haworth; A K Burroughs
Journal: Br Med J Date: 1977-10-01

3. Potentially dangerous effect of disopyramide on atrioventricular conduction in a patient on digitalis.

Authors: M Lara; G D Oakley; D Rowbotham
Journal: Br Med J Date: 1980-07-19

4. Intravenous sotalol for the treatment of atrial fibrillation and flutter after cardiopulmonary bypass. Comparison with disopyramide and digoxin in a randomised trial.

Authors: T J Campbell; T P Gavaghan; J J Morgan
Journal: Br Heart J Date: 1985-07

5. Disopyramide serum and pharmacologic effect kinetics applied to the assessment of bioavailability.

Authors: S M Bryson; B Whiting; J R Lawrence
Journal: Br J Clin Pharmacol Date: 1978-11 Impact factor: 4.335

6. Disopyramide induced second and third degree atrioventricular block in patients with bifascicular block. An acute stress test to predict atrioventricular block progression.

Authors: L Bergfeldt; M Rosenqvist; H Vallin; O Edhag
Journal: Br Heart J Date: 1985-03

7. Efficacy of intravenous disopyramide in acute cardiac arrhythmias.

Authors: M De Backer; E Stoupel; R J Kahn
Journal: Eur J Clin Pharmacol Date: 1981-01 Impact factor: 2.953

8. Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation.

Authors: Niels Voigt; Nadiia Rozmaritsa; Anne Trausch; Thomasz Zimniak; Torsten Christ; Erich Wettwer; Klaus Matschke; Dobromir Dobrev; Ursula Ravens
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2009-09-17 Impact factor: 3.000

Review 9. Disopyramide. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in cardiac arrhythmias.

Authors: R N Brogden; P A Todd
Journal: Drugs Date: 1987-08 Impact factor: 9.546

10. Comparative class 1 electrophysiologic and anticholinergic effects of disopyramide and its main metabolite (mono-N-dealkylated disopyramide) in healthy humans.

Authors: L Bergfeldt; K Schenck-Gustafsson; R Dahlqvist
Journal: Cardiovasc Drugs Ther Date: 1992-10 Impact factor: 3.727