Literature DB >> 8840024

Increased expression of NLRR-3 mRNA after cortical brain injury in mouse.

N Ishii1, A Wanaka, M Tohyama.   

Abstract

In Drosophila, members of the leucine-rich repeat (LRR) family have significant functions in neural development. We have isolated mouse brain cDNAs which encode three new independent LRR proteins (neuronal leucine-rich repeat: NLRR-1, NLRR-2, NLRR-3). Levels of expression of these NLRR mRNAs were measured in a unilateral cortical injury model by in-situ hybridization and Northern blot analysis. In the injured cerebral cortex, only NLRR-3 mRNA increased in layers 2-3, while the other two genes showed no up-regulation. The level of NLRR-3 mRNA induction peaked around 7-10 days postinjury. This study suggests that NLRR-3 may be an important component of the pathophysiological response to brain injury.

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Year:  1996        PMID： 8840024     DOI： 10.1016/0169-328x(96)00090-3

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  6 in total

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5.  A conserved gene family encodes transmembrane proteins with fibronectin, immunoglobulin and leucine-rich repeat domains (FIGLER).

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6.  Examination of NRCAM, LRRN3, KIAA0716, and LAMB1 as autism candidate genes.

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  6 in total

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