Literature DB >> 8839217

Organochlorine compounds in human brain.

F M Corrigan1, M French, L Murray.   

Abstract

Having observed polychlorinated biphenyls (PCBs) in brain tissue obtained post mortem from two men we have carried out a study of organochlorine compounds in frontal cortex from patients with Parkinson's disease (PD) and from controls. No PCBs were found in any of those samples. There was no difference in the concentration of the DDT metabolite pp'-DDE in the PD brain samples. Dieldrin (HEOD) was significantly decreased in PD brain when analysed by lipid weight. While these findings would not support the hypothesis that PCBs may contribute to the development of Parkinson's disease in humans it remains possible that they may cause damage to the basal ganglia before being displaced from brain tissue.

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Year:  1996        PMID： 8839217     DOI： 10.1177/096032719601500314

Source DB:  PubMed          Journal:  Hum Exp Toxicol        ISSN： 0960-3271            Impact factor:   2.903


  14 in total

1.  Cellular localization of dieldrin and structure-activity relationship of dieldrin analogues in dopaminergic cells.

Authors:  Erin M G Allen; Virginia R Florang; Laurie L Davenport; Yunden Jinsmaa; Jonathan A Doorn
Journal:  Chem Res Toxicol       Date:  2013-06-27       Impact factor: 3.739

2.  Environmental neurotoxic pesticide dieldrin activates a non receptor tyrosine kinase to promote PKCδ-mediated dopaminergic apoptosis in a dopaminergic neuronal cell model.

Authors:  Hariharan Saminathan; Arunkumar Asaithambi; Vellareddy Anantharam; Anumantha G Kanthasamy; Arthi Kanthasamy
Journal:  Neurotoxicology       Date:  2011-07-23       Impact factor: 4.294

Review 3.  Agrochemicals, α-synuclein, and Parkinson's disease.

Authors:  Blanca A Silva; Leonid Breydo; Anthony L Fink; Vladimir N Uversky
Journal:  Mol Neurobiol       Date:  2012-08-30       Impact factor: 5.590

4.  2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice.

Authors:  Izabela Kania-Korwel; Christopher D Barnhart; Marianna Stamou; Kim M Truong; Mohammed H M E El-Komy; Pamela J Lein; Peter Veng-Pedersen; Hans-Joachim Lehmler
Journal:  Environ Sci Technol       Date:  2012-09-28       Impact factor: 9.028

5.  Effect of HCH contamination of diet on the growth performance and immune and antioxidant ability in growing/finishing pigs.

Authors:  F Wang; Z R Xu; J H Sun; J H Su
Journal:  Vet Res Commun       Date:  2006-08       Impact factor: 2.459

6.  Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation.

Authors:  Dharmin Rokad; Shivani Ghaisas; Dilshan S Harischandra; Huajun Jin; Vellareddy Anantharam; Arthi Kanthasamy; Anumantha G Kanthasamy
Journal:  Brain Res Bull       Date:  2016-12-16       Impact factor: 4.077

7.  Developmental exposure to the organochlorine insecticide endosulfan damages the nigrostriatal dopamine system in male offspring.

Authors:  W Wyatt Wilson; Lauren P Shapiro; Joshua M Bradner; W Michael Caudle
Journal:  Neurotoxicology       Date:  2014-08-02       Impact factor: 4.294

8.  Exposure to the polybrominated diphenyl ether mixture DE-71 damages the nigrostriatal dopamine system: role of dopamine handling in neurotoxicity.

Authors:  Joshua M Bradner; Tiffany A Suragh; W Wyatt Wilson; Carlos R Lazo; Kristen A Stout; Hye Mi Kim; Min Z Wang; Douglas I Walker; Kurt D Pennell; Jason R Richardson; Gary W Miller; W Michael Caudle
Journal:  Exp Neurol       Date:  2012-12-31       Impact factor: 5.330

9.  Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: relevance to epigenetic mechanisms of neurodegeneration.

Authors:  C Song; A Kanthasamy; V Anantharam; F Sun; A G Kanthasamy
Journal:  Mol Pharmacol       Date:  2010-01-22       Impact factor: 4.436

10.  Postmortem studies in Parkinson's disease.

Authors:  Andreas Hartmann
Journal:  Dialogues Clin Neurosci       Date:  2004-09       Impact factor: 5.986
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