Literature DB >> 8838976

Ehlers-Danlos syndrome: relationship between joint hypermobility, urinary incontinence, and pelvic floor prolapse.

L J McIntosh1, D F Stanitski, V T Mallett, J D Frahm, D A Richardson, M I Evans.   

Abstract

OBJECTIVE: To compare the incidence of joint hypermobility and prolapse in incontinent and continent women with Ehlers-Danlos syndrome (EDS).
METHODS: Forty-six patients with EDS were evaluated by history and physical examination. The degree of joint mobility of shoulder, elbow, wrist, hip, knee, and ankle was evaluated by orthopedic surgeons and physical therapists. Joint range of motion measurements were obtained using an orthopedic goniometer.
RESULTS: The two EDS groups, incontinent (n = 28) and continent (n = 18) women, had a statistically similar mean age, weight, and parity (p = NS). In the EDS population overall joint hypermobility averaged 34.3%. Individuals with EDS type 3 had significantly more joint hypermobility than those with type 1 and 2 EDS. However, logistic regression analysis demonstrated no significant relationship between prolapse and joint hypermobility. Wrist dorsiflexion (p < 0.05) and palmar flexion (p = 0.05) were the only variables related to incontinence.
CONCLUSION: It has previously been reported that hypermobility was correlated with pelvic floor prolapse. Of 18 joint measures per patient, hypermobility of both wrist dorsiflexion and palmar flexion was associated with symptoms of incontinence. We were unable to document an association between joint hypermobility and prolapse in the EDS population.

Entities:  

Mesh:

Year:  1996        PMID: 8838976     DOI: 10.1159/000292060

Source DB:  PubMed          Journal:  Gynecol Obstet Invest        ISSN: 0378-7346            Impact factor:   2.031


  6 in total

Review 1.  Urogenital and pelvic complications in the Ehlers-Danlos syndromes and associated hypermobility spectrum disorders: A scoping review.

Authors:  Elizabeth Gilliam; Jodi D Hoffman; Gloria Yeh
Journal:  Clin Genet       Date:  2019-09-01       Impact factor: 4.438

Review 2.  Non-cardiac manifestations of Marfan syndrome.

Authors:  Anne H Child
Journal:  Ann Cardiothorac Surg       Date:  2017-11

Review 3.  Joint hypermobility, obstetrical outcomes, and pelvic floor disorders.

Authors:  Leise R Knoepp; Kelly C McDermott; Alvaro Muñoz; Joan L Blomquist; Victoria L Handa
Journal:  Int Urogynecol J       Date:  2012-08-17       Impact factor: 2.894

Review 4.  Approach to a woman with urinary incontinence.

Authors:  Manidip Pal; Abhijit Halder; Soma Bandyopadhyay
Journal:  Urol Ann       Date:  2019-11-07

Review 5.  Association between joint hypermobility and pelvic organ prolapse in women: a systematic review and meta-analysis.

Authors:  Nikolaus Veit-Rubin; Rufus Cartwright; Anand U Singh; G Alessandro Digesu; Ruwan Fernando; Vikram Khullar
Journal:  Int Urogynecol J       Date:  2015-12-10       Impact factor: 2.894

6.  Multisystemic manifestations in a cohort of 75 classical Ehlers-Danlos syndrome patients: natural history and nosological perspectives.

Authors:  Marco Ritelli; Marina Venturini; Valeria Cinquina; Nicola Chiarelli; Marina Colombi
Journal:  Orphanet J Rare Dis       Date:  2020-07-31       Impact factor: 4.123

  6 in total

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