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Literature DB >> 8838791

Screening of the macromolecular component of CSF from various pathologies for its interference with GABAA receptor function.

Abstract

Cerebrospinal fluid (CSF) samples from patients undergoing lumbar puncture for suspected neurological diseases were fractioned into macromolecular (MW > 3000 Daltons) and small molecule components (MW < 3000 Daltons). The macromolecular component was tested for its interference with GABA stimulation of 36Cl- accumulation in rat cerebral cortex microsacs. For many pathologies, no interference was apparent; an exception was two patients with Parkinson's disease in whom there were clear signs of stimulated GABA activity. This last result seems worthy of further investigation.

Entities: Chemical Disease Species

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Year: 1995 PMID： 8838791 DOI： 10.1007/bf02230915

Source DB: PubMed Journal: Ital J Neurol Sci ISSN： 0392-0461

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References

9 in total

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9 in total

Screening of the macromolecular component of CSF from various pathologies for its interference with GABAA receptor function.

Review 1. Excitatory amino acid neurotoxicity and neurodegenerative disease.

2. Stimulation of 36Cl- influx into rabbit cerebral cortex microsacs by the endogenous antigen S-100.

3. Antibodies in the CSF of a Parkinson patient recognizes neurons in rat mesencephalic regions.

4. Antibodies in cerebrospinal fluid of some Alzheimer disease patients recognize cholinergic neurons in the rat central nervous system.

5. Functional coupling of gamma-aminobutyric acid receptors to chloride channels in brain membranes.

Review 6. Molecular biology of GABAA receptors.

7. Detection of several novel gamma-aminobutyric acid-containing compounds in human CSF.

8. Antibody in the CSF of patients with multiple system atrophy reacts specifically with rat locus ceruleus.

9. Biochemical characterization of a filtered synaptoneurosome preparation from guinea pig cerebral cortex: cyclic adenosine 3':5'-monophosphate-generating systems, receptors, and enzymes.