OBJECTIVE: To clarify the effects of anticardiolipin antibodies (aCL) on pregnancy. METHODS: Monoclonal aCL obtained from MRL/lpr mice was administered to pregnant BALB/c mice and changes in the outcome of pregnancy were evaluated. RESULTS: The pregnant BALB/c mice injected with monoclonal aCL showed a higher intrauterine fetal death rate than controls, but there were no significant differences in platelet counts. We observed signs of placental infarction only in the placenta of the treated pregnant BALB/c mice. CONCLUSION: The intrauterine fetal deaths may have been due to thrombosis.
OBJECTIVE: To clarify the effects of anticardiolipin antibodies (aCL) on pregnancy. METHODS: Monoclonal aCL obtained from MRL/lpr mice was administered to pregnant BALB/c mice and changes in the outcome of pregnancy were evaluated. RESULTS: The pregnant BALB/c mice injected with monoclonal aCL showed a higher intrauterine fetal death rate than controls, but there were no significant differences in platelet counts. We observed signs of placental infarction only in the placenta of the treated pregnant BALB/c mice. CONCLUSION: The intrauterine fetal deaths may have been due to thrombosis.