Literature DB >> 8838460

Sensitivity of histamine H3 receptor agonist-stimulated [35S]GTP gamma[S] binding to pertussis toxin.

E A Clark1, S J Hill.   

Abstract

The effect of histamine H3 receptor-selective ligands on [35S]guanosine 5'-o-(gamma-thio)triphosphate ([35S]GTP gamma[S]) binding has been examined in rat cerebral cortical membranes. R alpha-Methylhistamine and N alpha-methylhistamine produced a concentration-dependent stimulation of [35S]GTP gamma[S] binding which was attenuated in the presence of the selective histamine H3 receptor antagonist thioperamide. In addition, treatment of brain membranes with pertussis toxin abolished the histamine H3 receptor agonist stimulated binding of [35S]GTP gamma[S]. These results provide the first evidence that histamine H3 receptors couple directly to a Gi/Go protein in mammalian brain.

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Year:  1996        PMID： 8838460     DOI： 10.1016/0014-2999(95)00800-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  20 in total

1.  Histamine H3-receptor-mediated [35S]GTP gamma[S] binding: evidence for constitutive activity of the recombinant and native rat and human H3 receptors.

Authors:  A Rouleau; X Ligneau; J Tardivel-Lacombe; S Morisset; F Gbahou; J-C Schwartz; J-M Arrang
Journal:  Br J Pharmacol       Date:  2002-01       Impact factor: 8.739

Review 2.  The histamine H3 receptor: an attractive target for the treatment of cognitive disorders.

Authors:  T A Esbenshade; K E Browman; R S Bitner; M Strakhova; M D Cowart; J D Brioni
Journal:  Br J Pharmacol       Date:  2008-05-12       Impact factor: 8.739

3.  The expression and function of histamine H₃ receptors in pancreatic beta cells.

Authors:  T Nakamura; T Yoshikawa; N Noguchi; A Sugawara; A Kasajima; H Sasano; K Yanai
Journal:  Br J Pharmacol       Date:  2014-01       Impact factor: 8.739

4.  Novel histamine H(3)-receptor antagonists and partial agonists with a non-aminergic structure.

Authors:  T Nickel; U Bauer; E Schlicker; M Kathmann; M Göthert; A Sasse; H Stark; W Schunack
Journal:  Br J Pharmacol       Date:  2001-04       Impact factor: 8.739

5.  Histamine receptors in mammalian retinas.

Authors:  Matthew J Gastinger; Alistair J Barber; Noga Vardi; David W Marshak
Journal:  J Comp Neurol       Date:  2006-04-20       Impact factor: 3.215

6.  Mepyramine but not cimetidine or clobenpropit blocks pertussis toxin-induced histamine sensitization in rats.

Authors:  W Vleeming; C F Hendriksen; A van de Kuil; J W van den Hout; D J de Wildt
Journal:  Br J Pharmacol       Date:  2000-04       Impact factor: 8.739

7.  Histaminergic modulation of GABAergic transmission in rat ventromedial hypothalamic neurones.

Authors:  I S Jang; J S Rhee; T Watanabe; N Akaike; N Akaike
Journal:  J Physiol       Date:  2001-08-01       Impact factor: 5.182

8.  [3H]-thioperamide as a radioligand for the histamine H3 receptor in rat cerebral cortex.

Authors:  A Alves-Rodrigues; R Leurs; T S Wu; G D Prell; C Foged; H Timmerman
Journal:  Br J Pharmacol       Date:  1996-08       Impact factor: 8.739

9.  Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, potentiates neurochemical and behavioral effects of haloperidol in the rat.

Authors:  Catherine Pillot; Jordi Ortiz; Anne Héron; Sophie Ridray; Jean-Charles Schwartz; Jean-Michel Arrang
Journal:  J Neurosci       Date:  2002-08-15       Impact factor: 6.167

10.  Histamine, carbachol, and serotonin induce hyperresponsiveness to ATP in guinea pig tracheas: involvement of COX-2 pathway.

Authors:  Luis M Montaño; Verónica Carbajal; Mario H Vargas; Luz M García-Hernández; Verónica Díaz-Hernández; Marco Checa; Carlos Barajas-López
Journal:  Pflugers Arch       Date:  2013-03-10       Impact factor: 3.657
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