Literature DB >> 8835644

Assessment of protein kinase C mRNA levels in Alzheimer's disease brains.

M Chachin1, S Shimohama, Y U Kunugi, T Taniguchi.   

Abstract

We have previously demonstrated that the protein level of type beta protein kinase C (PKC) was significantly reduced in Alzheimer's disease (AD) brains compared to controls. To clarify whether this is due to decreased synthesis and/or increased degradation of PKC, the present study was performed to examine mRNA levels of PKC isozymes in control and AD brains. The present study indicated that mRNA levels of types alpha, beta and gamma PKC were not significantly changed in the control and AD brains. Thus, the reduction of type beta PKC protein content in AD brains might be caused by increased degradation.

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Year:  1996        PMID： 8835644     DOI： 10.1254/jjp.71.175

Source DB:  PubMed          Journal:  Jpn J Pharmacol        ISSN： 0021-5198


  5 in total

Review 1.  Isoenzymes of protein kinase C: differential involvement in apoptosis and pathogenesis.

Authors:  E M Deacon; J Pongracz; G Griffiths; J M Lord
Journal:  Mol Pathol       Date:  1997-06

Review 2.  Ionic and signal transduction alterations in Alzheimer's disease: relevance of studies on peripheral cells.

Authors:  R Etcheberrigaray; S Bhagavan
Journal:  Mol Neurobiol       Date:  1999 Oct-Dec       Impact factor: 5.590

3.  Searching for disease modifiers-PKC activation and HDAC inhibition - a dual drug approach to Alzheimer's disease that decreases Abeta production while blocking oxidative stress.

Authors:  Alan P Kozikowski; Yihua Chen; Tapadar Subhasish; Nancy E Lewin; Peter M Blumberg; Zhenyu Zhong; Melissa A D'Annibale; Weng-Long Wang; Yong Shen; Brett Langley
Journal:  ChemMedChem       Date:  2009-07       Impact factor: 3.466

4.  Bryostatin-1 vs. TPPB: dose-dependent APP processing and PKC-α, -δ, and -ε isoform activation in SH-SY5Y neuronal cells.

Authors:  P Yi; L Schrott; T P Castor; J S Alexander
Journal:  J Mol Neurosci       Date:  2012-06-15       Impact factor: 3.444

5.  Sulfonic acid functionalized nano-γ-Al2O3: a new, efficient, and reusable catalyst for synthesis of 3-substituted-2H-1,4-benzothiazines.

Authors:  Wei Lin Li; Shuan Bao Tian; Feng Zhu
Journal:  ScientificWorldJournal       Date:  2013-07-14
  5 in total

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