H S El-Kadi1, L B Keil, V A DeBari. 1. Department of Medicine, Seton Hall University School of Graduate Medical Education, Paterson, New Jersey, USA.
Abstract
OBJECTIVE: To examine IgG anti-beta 2 glycoprotein I (anti-beta 2 GPI) binding in 82 sera referred for anticardiolipin antibody (aCL) testing and to develop preliminary clinical correlations with antiphospholipid syndrome (APS). METHODS: Immunoassay of IgG cofactor dependent aCL and IgG anti-beta 2 GPI antibodies and retrospective chart review. RESULTS: Forty-four sera exhibited normal (< or = 22 GPL units) aCL activity, 18 had moderate binding activity (23-45 GPL units), and 20 had high (> or = 46 GPL units) binding activity to cardiolipin. Among these groups, 6 of the 20 sera in the high GPL group had elevated anti-beta 2 GPI. This correlated strongly with 2 or more clinical manifestations of APS. CONCLUSION: Anti-beta 2 GPI activity may be a more valuable indicator of APS than aCL.
OBJECTIVE: To examine IgG anti-beta 2 glycoprotein I (anti-beta 2 GPI) binding in 82 sera referred for anticardiolipin antibody (aCL) testing and to develop preliminary clinical correlations with antiphospholipid syndrome (APS). METHODS: Immunoassay of IgG cofactor dependent aCL and IgG anti-beta 2 GPI antibodies and retrospective chart review. RESULTS: Forty-four sera exhibited normal (< or = 22 GPL units) aCL activity, 18 had moderate binding activity (23-45 GPL units), and 20 had high (> or = 46 GPL units) binding activity to cardiolipin. Among these groups, 6 of the 20 sera in the high GPL group had elevated anti-beta 2 GPI. This correlated strongly with 2 or more clinical manifestations of APS. CONCLUSION: Anti-beta 2 GPI activity may be a more valuable indicator of APS than aCL.
Authors: N Di Simone; P L Meroni; N de Papa; E Raschi; D Caliandro; C S De Carolis; M A Khamashta; T Atsumi; G R Hughes; G Balestrieri; A Tincani; P Casali; A Caruso Journal: Arthritis Rheum Date: 2000-01
Authors: I E Koutroubakis; E Petinaki; E Anagnostopoulou; H Kritikos; I A Mouzas; E A Kouroumalis; O N Manousos Journal: Dig Dis Sci Date: 1998-11 Impact factor: 3.199