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Literature DB >> 8834915

(-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (524W91) inhibits hepatitis B virus replication in primary human hepatocytes.

L D Condreay¹, J P Condreay, R W Jansen, M T Paff, D R Averett.

Abstract

The anti-hepatitis B virus (HBV) activity of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (524W91) in cultures of primary human hepatocytes was examined. 524W91 was anabolized to the active 5'-triphosphate in these cells. HBV replication was equally inhibited in cultures incubated with 524W91 when the drug was added 24 h preinfection, at infection, or 24 h postinfection. 524W91 inhibited HBV replication by 50% at less than 20 nM in human hepatocytes.

Entities: Chemical Disease Species

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Year: 1996 PMID： 8834915 PMCID： PMC163151

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

15 in total

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Journal: In Vitro Cell Dev Biol Date: 1989-02

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Authors: B L Kreamer; J L Staecker; N Sawada; G L Sattler; M T Hsia; H C Pitot
Journal: In Vitro Cell Dev Biol Date: 1986-04

4. Stable expression and replication of hepatitis B virus genome in an integrated state in a human hepatoma cell line transfected with the cloned viral DNA.

Authors: T Tsurimoto; A Fujiyama; K Matsubara
Journal: Proc Natl Acad Sci U S A Date: 1987-01 Impact factor: 11.205

5. Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA.

Authors: M A Sells; M L Chen; G Acs
Journal: Proc Natl Acad Sci U S A Date: 1987-02 Impact factor: 11.205

6. An in vitro system for infection with hepatitis B virus that uses primary human fetal hepatocytes.

Authors: T Ochiya; T Tsurimoto; K Ueda; K Okubo; M Shiozawa; K Matsubara
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7. Isolation, culture, and transplantation of human hepatocytes.

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8. Replicative intermediates of hepatitis B virus in HepG2 cells that produce infectious virions.

Authors: M A Sells; A Z Zelent; M Shvartsman; G Acs
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9. Cellular metabolism of 2',3'-dideoxycytidine, a compound active against human immunodeficiency virus in vitro.

Authors: M C Starnes; Y C Cheng
Journal: J Biol Chem Date: 1987-01-25 Impact factor: 5.157

10. Cellular pharmacology of 2',3'-dideoxy-2',3'-didehydrothymidine, a nucleoside analog active against human immunodeficiency virus.

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3 in total