Literature DB >> 8834906

Enzymatic method for inactivation of aminoglycosides during measurement of postantibiotic effect.

J G den Hollander1, J W Mouton, I A Bakker-Woudenberg, F P Vleggaar, M P van Goor, H A Verbrugh.   

Abstract

To determine the postantibiotic effect of aminoglycosides, two methods are currently being used to remove the test drug: repeated washing and dilution. An enzymatic inactivation method of removing gentamicin and tobramycin was developed and compared with the dilution method. This enzymatic method provides a rapid and simple alternative method of removing aminoglycosides which results in reliable postantibiotic-effect values.

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Year:  1996        PMID： 8834906      PMCID： PMC163142     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  6 in total

1.  Action of Penicillin on Staphylococcus.

Authors:  R F Parker; H C Marsh
Journal:  J Bacteriol       Date:  1946-02       Impact factor: 3.490

2.  Once-daily dosing regimen for aminoglycoside plus beta-lactam combination therapy of serious bacterial infections: comparative trial with netilmicin plus ceftriaxone.

Authors:  E W ter Braak; P J de Vries; K P Bouter; S G van der Vegt; G C Dorrestein; J W Nortier; A van Dijk; R P Verkooyen; H A Verbrugh
Journal:  Am J Med       Date:  1990-07       Impact factor: 4.965

Review 3.  The post-antibiotic effect.

Authors:  F M MacKenzie; I M Gould
Journal:  J Antimicrob Chemother       Date:  1993-10       Impact factor: 5.790

4.  Postantibiotic effect of aminoglycosides on staphylococci.

Authors:  B Isaksson; R Maller; L E Nilsson; M Nilsson
Journal:  J Antimicrob Chemother       Date:  1993-08       Impact factor: 5.790

5.  Postantibiotic effect of aminoglycosides on gram-negative bacteria evaluated by a new method.

Authors:  B Isaksson; L Nilsson; R Maller; L Sörén
Journal:  J Antimicrob Chemother       Date:  1988-07       Impact factor: 5.790

6.  Impact of pH and cationic supplementation on in vitro postantibiotic effect.

Authors:  A Gudmundsson; H Erlendsdottir; M Gottfredsson; S Gudmundsson
Journal:  Antimicrob Agents Chemother       Date:  1991-12       Impact factor: 5.191
  6 in total
  4 in total

1.  Alteration of postantibiotic effect during one dosing interval of tobramycin, simulated in an in vitro pharmacokinetic model.

Authors:  J G den Hollander; J W Mouton; M P van Goor; F P Vleggaar; H A Verbrugh
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

2.  Duration and clinical relevance of postantibiotic effect in relation to the dosing interval.

Authors:  J G den Hollander; K Fuursted; H A Verbrugh; J W Mouton
Journal:  Antimicrob Agents Chemother       Date:  1998-04       Impact factor: 5.191

3.  Therapeutic efficacy of liposome-encapsulated gentamicin in rat Klebsiella pneumoniae pneumonia in relation to impaired host defense and low bacterial susceptibility to gentamicin.

Authors:  R M Schiffelers; G Storm; M T ten Kate; I A Bakker-Woudenberg
Journal:  Antimicrob Agents Chemother       Date:  2001-02       Impact factor: 5.191

4.  Pharmacokinetics and efficacies of liposomal and conventional formulations of tobramycin after intratracheal administration in rats with pulmonary Burkholderia cepacia infection.

Authors:  Jean-Francois Marier; Jean Lavigne; Murray P Ducharme
Journal:  Antimicrob Agents Chemother       Date:  2002-12       Impact factor: 5.191
  4 in total

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