Literature DB >> 8834766

IL-6 cytokine family and signal transduction: a model of the cytokine system.

M Hibi1, K Nakajima, T Hirano.   

Abstract

The interleukin 6 (IL-6) cytokine family, which includes IL-6, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), IL-11 and cardiotrophin-1 (CT-1), exhibits pleiotropy and redundancy in biological activities. The IL-6 family cytokines exhibit a helical structure. Their receptors belong to the type 1 cytokine receptor family. The receptors of the IL-6 family cytokines share a receptor subunit, which explains one of the mechanisms of functional redundancy. In this review, we describe the general features of the IL-6 cytokine family and its signal transduction mechanisms. Many functional properties of the IL-6 family of cytokines and their receptors are general features of the cytokine system.

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Year:  1996        PMID： 8834766     DOI： 10.1007/bf00202068

Source DB:  PubMed          Journal:  J Mol Med (Berl)        ISSN： 0946-2716            Impact factor:   4.599


  163 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

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Journal:  Cytokine       Date:  1990-09       Impact factor: 3.861

5.  Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter.

Authors:  X Y Fu; J J Zhang
Journal:  Cell       Date:  1993-09-24       Impact factor: 41.582

6.  Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.

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Journal:  Science       Date:  1994-01-07       Impact factor: 47.728

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Journal:  Proc Natl Acad Sci U S A       Date:  1995-06-06       Impact factor: 11.205

9.  Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

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Journal:  J Exp Med       Date:  1989-09-01       Impact factor: 14.307

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  43 in total

Review 1.  Rosacea: The cytokine and chemokine network.

Authors:  Peter Arne Gerber; Bettina Alexandra Buhren; Martin Steinhoff; Bernhard Homey
Journal:  J Investig Dermatol Symp Proc       Date:  2011-12

Review 2.  Molecular mechanisms of alcoholic liver disease: innate immunity and cytokines.

Authors:  Andrew M Miller; Norio Horiguchi; Won-Il Jeong; Svetlana Radaeva; Bin Gao
Journal:  Alcohol Clin Exp Res       Date:  2011-02-01       Impact factor: 3.455

3.  Contribution of Fibroblast and Mast Cell (Afferent) and Tumor (Efferent) IL-6 Effects within the Tumor Microenvironment.

Authors:  Honor J Hugo; Stephanie Lebret; Eva Tomaskovic-Crook; Nuzhat Ahmed; Tony Blick; Donald F Newgreen; Erik W Thompson; M Leigh Ackland
Journal:  Cancer Microenviron       Date:  2012-02-08

4.  Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells.

Authors:  Christiane Stuhlmann-Laeisz; Sigrid Lang; Athena Chalaris; Paliga Krzysztof; Sudarman Enge; Jutta Eichler; Ursula Klingmüller; Michael Samuel; Matthias Ernst; Stefan Rose-John; Jürgen Scheller
Journal:  Mol Biol Cell       Date:  2006-04-19       Impact factor: 4.138

5.  Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase.

Authors:  M Takahashi-Tezuka; Y Yoshida; T Fukada; T Ohtani; Y Yamanaka; K Nishida; K Nakajima; M Hibi; T Hirano
Journal:  Mol Cell Biol       Date:  1998-07       Impact factor: 4.272

Review 6.  A primer on cytokines: sources, receptors, effects, and inducers.

Authors:  J H Curfs; J F Meis; J A Hoogkamp-Korstanje
Journal:  Clin Microbiol Rev       Date:  1997-10       Impact factor: 26.132

7.  JAK1/STAT3 Activation through a Proinflammatory Cytokine Pathway Leads to Resistance to Molecularly Targeted Therapy in Non-Small Cell Lung Cancer.

Authors:  Kazuhiko Shien; Vassiliki A Papadimitrakopoulou; Dennis Ruder; Carmen Behrens; Li Shen; Neda Kalhor; Juhee Song; J Jack Lee; Jing Wang; Ximing Tang; Roy S Herbst; Shinichi Toyooka; Luc Girard; John D Minna; Jonathan M Kurie; Ignacio I Wistuba; Julie G Izzo
Journal:  Mol Cancer Ther       Date:  2017-07-20       Impact factor: 6.261

Review 8.  Muscle-derived interleukin-6: possible biological effects.

Authors:  B K Pedersen; A Steensberg; P Schjerling
Journal:  J Physiol       Date:  2001-10-15       Impact factor: 5.182

9.  Hepatocellular hyperplasia, plasmacytoma formation, and extramedullary hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic mice.

Authors:  P Schirmacher; M Peters; G Ciliberto; M Blessing; J Lotz; K H Meyer zum Büschenfelde; S Rose-John
Journal:  Am J Pathol       Date:  1998-08       Impact factor: 4.307

10.  Expression of ciliary neurotrophic factor (CNTF) and its tripartite receptor complex by cells of the human optic nerve head.

Authors:  Xiaochun Liu; Abbot F Clark; Robert J Wordinger
Journal:  Mol Vis       Date:  2007-05-23       Impact factor: 2.367
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