Literature DB >> 8834534

Filament heterogeneity within the dystrophic neurites of senile plaques suggests blockage of fast axonal transport in Alzheimer's disease.

D Praprotnik1, M A Smith, P L Richey, H V Vinters, G Perry.   

Abstract

In this study, the direct comparison of biopsy and autopsy tissue by morphological and immunocytochemical techniques, respectively, was used to document cytoskeletal changes of dystrophic neurites (DN) of senile plaques in Alzheimer's disease. This dual approach demonstrated several unreported abnormalities which, together with analogous findings in several experimental models, suggest that DN are associated with deficiencies in fast axonal transport and replacement of the cytoskeleton by an array of related abnormal filaments.

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Year:  1996        PMID： 8834534     DOI： 10.1007/s004010050420

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


  24 in total

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Review 8.  Alzheimer's disease as homeostatic responses to age-related myelin breakdown.

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9.  Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo.

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