Literature DB >> 8834243

Identification of three new microsatellite markers in the spinocerebellar ataxia type 2 (SCA2) region and 1.2 Mb physical map.

T Nechiporuk1, A Nechiporuk, X Guan, R Frederick, K Figueroa, I Chumakov, J R Korenberg, P J de Jong, S M Pulst.   

Abstract

Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disease recently mapped to chromosome 12q close to the locus D12S84 by genetic linkage analysis. To generate additional genetic markers in the SCA2 region, we constructed a physical map of the region using yeast artificial chomosome (YAC), P1 artificial chromosome (PAC) and cosmid clones. The physical map was found to agree well with the genetic map. Three novel microsatellite markers were isolated and physically mapped. A novel approach to isolate CAG repeats directly from YAC DNAs is described.

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Year:  1996        PMID： 8834243     DOI： 10.1007/bf02267067

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  14 in total

1.  Fluorescence in situ hybridization of YAC clones after Alu-PCR amplification.

Authors:  C Lengauer; E D Green; T Cremer
Journal:  Genomics       Date:  1992-07       Impact factor: 5.736

2.  Characterization of (CA)n microsatellites with degenerate sequencing primers.

Authors:  D L Browne; M Litt
Journal:  Nucleic Acids Res       Date:  1992-01-11       Impact factor: 16.971

3.  The 1993-94 Généthon human genetic linkage map.

Authors:  G Gyapay; J Morissette; A Vignal; C Dib; C Fizames; P Millasseau; S Marc; G Bernardi; M Lathrop; J Weissenbach
Journal:  Nat Genet       Date:  1994-06       Impact factor: 38.330

4.  A new bacteriophage P1-derived vector for the propagation of large human DNA fragments.

Authors:  P A Ioannou; C T Amemiya; J Garnes; P M Kroisel; H Shizuya; C Chen; M A Batzer; P J de Jong
Journal:  Nat Genet       Date:  1994-01       Impact factor: 38.330

5.  Yeast artificial chromosomes: an alternative approach to the molecular analysis of mouse developmental mutations.

Authors:  Z Larin; H Lehrach
Journal:  Genet Res       Date:  1990 Oct-Dec       Impact factor: 1.588

6.  CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1.

Authors:  Y Kawaguchi; T Okamoto; M Taniwaki; M Aizawa; M Inoue; S Katayama; H Kawakami; S Nakamura; M Nishimura; I Akiguchi
Journal:  Nat Genet       Date:  1994-11       Impact factor: 38.330

7.  Confirmation of the SCA-2 locus as an alternative locus for dominantly inherited spinocerebellar ataxias and refinement of the candidate region.

Authors:  I Lopes-Cendes; E Andermann; E Attig; F Cendes; S Bosch; M Wagner; F Gerstenbrand; F Andermann; G A Rouleau
Journal:  Am J Hum Genet       Date:  1994-05       Impact factor: 11.025

8.  Chromosomal assignment of the second locus for autosomal dominant cerebellar ataxia (SCA2) to chromosome 12q23-24.1.

Authors:  S Gispert; R Twells; G Orozco; A Brice; J Weber; L Heredero; K Scheufler; B Riley; R Allotey; C Nothers
Journal:  Nat Genet       Date:  1993-07       Impact factor: 38.330

9.  Clinical and genetic analysis of a Tunisian family with autosomal dominant cerebellar ataxia type 1 linked to the SCA2 locus.

Authors:  S Belal; G Cancel; G Stevanin; F Hentati; C Khati; C Ben Hamida; G Auburger; Y Agid; M Ben Hamida; A Brice
Journal:  Neurology       Date:  1994-08       Impact factor: 9.910

10.  Identification and characterization of the gene causing type 1 spinocerebellar ataxia.

Authors:  S Banfi; A Servadio; M Y Chung; T J Kwiatkowski; A E McCall; L A Duvick; Y Shen; E J Roth; H T Orr; H Y Zoghbi
Journal:  Nat Genet       Date:  1994-08       Impact factor: 38.330
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