| Literature DB >> 8833772 |
P D Feldman1, N Parveen, S Sezen.
Abstract
Microinjections of Leu-enkephalin into the dorsal vagal complex induced hypotension and bradycardia. Both naloxone, given at a dose conferring selectivity for mu receptors, and the delta antagonist ICI 154,129 prevented the cardiovascular effects of Leu-enkephalin. Naloxone was also found to decrease the gain of the baroreflex. These results suggest that Leu-enkephalin is involved in cardiovascular regulation through activation of delta-, and possibly mu-, opioid receptors in the dorsal vagal complex.Entities:
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Year: 1996 PMID： 8833772 DOI： 10.1016/0006-8993(95)01434-9
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252