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Literature DB >> 8833497

Amiodarone in a newborn with ventricular tachycardia and an intracardiac tumor: adjusting the dose according to an individualized dosing regimen.

T Bouillon¹, H Schiffmann, D Bartmus, U Gundert-Remy.

Abstract

We report the successful management of recurrent ventricular tachycardias in a newborn suffering from an intracardiac tumor. Amiodarone was the only agent able to control the tachycardias and did so as long as an individually titrated plasma concentration above 0.8 mu mol/L was maintained. Because no therapeutic plasma concentration has been defined in children and no kinetic studies are available in this population, we optimized the dosing regimen based on a computer simulation, taking into account the pharmacokinetic parameters of the patient and the individual concentration-effect relation.

Entities: Chemical Disease Species

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Year: 1996 PMID： 8833497 DOI： 10.1007/BF02505094

Source DB: PubMed Journal: Pediatr Cardiol ISSN： 0172-0643 Impact factor: 1.655

11 in total

3. Congenital giant cardiac tumor with severe left-ventricular inflow and outflow obstruction and arrhythmia treated with pulmonary artery banding and long-term amiodarone infusion.

Authors: Daiji Takeuchi; Takeshi Hiramatsu; Toshio Nakanishi
Journal: Ann Pediatr Cardiol Date: 2012-01

3 in total

Amiodarone in a newborn with ventricular tachycardia and an intracardiac tumor: adjusting the dose according to an individualized dosing regimen.

1. Newer antiarrhythmic drugs in children.

2. Long-term follow-up of amiodarone therapy in the young: continued efficacy, unimpaired growth, moderate side effects.

Review 3. Amiodarone therapeutic plasma concentration monitoring. Is it practical?

4. Efficacy and safety of amiodarone in infants.

5. Efficacy and safety of long-term amiodarone in treatment of cardiac arrhythmias: dosage experience.

6. Pharmacokinetics of amiodarone after intravenous and oral administration.

Review 7. Clinical pharmacokinetics of amiodarone.

8. Amiodarone kinetics after oral doses.

9. Amiodarone in the treatment of cardiac arrhythmias in children: one hundred thirty-five cases.

10. Intravenous and oral amiodarone for arrhythmias in children.

1. Acute hemodynamic effects of intravenous amiodarone treatment in paediatric cardiac surgical patients.

2. Ventricular tachycardia in a neonate with prenatally diagnosed cardiac tumors: a case with tuberous sclerosis.

3. Congenital giant cardiac tumor with severe left-ventricular inflow and outflow obstruction and arrhythmia treated with pulmonary artery banding and long-term amiodarone infusion.