Literature DB >> 8833060

Initial experience combining methotrexate with biologic agents for treating rheumatoid arthritis.

L W Moreland1.   

Abstract

The combination of traditional disease modifying antirheumatic drugs such as methotrexate (MTX) with biologic agents for treating rheumatoid arthritis (RA) has thus far been limited. The combination of MTX and a depleting anti-CD4 monoclonal antibody (cM-T412) has been evaluated in phase I and II trials in patients with refractory RA. The potential of combining MTX with other biologic agents is reviewed.

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Year:  1996        PMID: 8833060

Source DB:  PubMed          Journal:  J Rheumatol Suppl        ISSN: 0380-0903


  2 in total

Review 1.  Regulatory aspects of evaluating combination treatments in autoimmune diseases.

Authors:  P Kurki
Journal:  Springer Semin Immunopathol       Date:  2001

2.  Infliximab in combination with methotrexate in active ankylosing spondylitis: a clinical and imaging study.

Authors:  H Marzo-Ortega; D McGonagle; S Jarrett; G Haugeberg; E Hensor; P O'connor; A L Tan; P G Conaghan; A Greenstein; P Emery
Journal:  Ann Rheum Dis       Date:  2005-04-13       Impact factor: 19.103

  2 in total

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