| Literature DB >> 8831763 |
L Strekowski1, Y Gulevich, T C Baranowski, A N Parker, A S Kiselyov, S Y Lin, F A Tanious, W D Wilson.
Abstract
4-[N-(Aminoalkyl)amino]-2-arylquinolines with conformational freedom around positions 2 and 4 of the quinoline stabilize strongly poly(dT.dA.dT) (triplex DNA) and bind weakly to poly-(dA.dT) (duplex DNA). Basicity of N1 of the quinoline parallels the interaction strength of these compounds with the triple-helical DNA structure suggesting that N1 of the quinoline is protonated in the complex with the DNA triplex. The experimental results support the interaction model suggested previously.Entities:
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Year: 1996 PMID： 8831763 DOI： 10.1021/jm9603734
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446