Literature DB >> 8831756

Hypoglycemic activity of a series of alpha-alkylthio and alpha-alkoxy carboxylic acids related to ciglitazone.

B Hulin1, L S Newton, D M Lewis, P E Genereux, E M Gibbs, D A Clark.   

Abstract

The thiazolidinedione moiety of ciglitazone and its analogues can be replaced by an alpha-alkoxy or alpha-thioether carboxylic acid group. The influence of the nature of the R group, the length of the connector to the aromatic backbone of the molecule, and the stereochemistry have been studied. The most potent compounds have glucose-lowering activity at doses as low as 0.01 mg/kg.

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Year:  1996        PMID： 8831756     DOI： 10.1021/jm960230h

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  3 in total

1.  The PPAR-gamma agonist, darglitazone, restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouse.

Authors:  Rashmi Kumari; Lisa B Willing; Shyama D Patel; J Kyle Krady; William J Zavadoski; E Michael Gibbs; Susan J Vannucci; Ian A Simpson
Journal:  J Cereb Blood Flow Metab       Date:  2009-10-28       Impact factor: 6.200

Review 2.  Biological Rationale for the Use of PPARγ Agonists in Glioblastoma.

Authors:  Hayley Patricia Ellis; Kathreena Mary Kurian
Journal:  Front Oncol       Date:  2014-03-14       Impact factor: 6.244

Review 3.  Recent pharmacological developments on rhodanines and 2,4-thiazolidinediones.

Authors:  Ravinder Singh Bhatti; Sakshi Shah; Pawan Krishan; Jagir S Sandhu
Journal:  Int J Med Chem       Date:  2013-05-02
  3 in total

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