UNLABELLED: To assess the airway response to inhaled tobramycin we measured flow volume curves in 12 patients with cystic fibrosis. Immediately and/or 2 min after tobramycin inhalations there was a significant fall in lung function regardless of the concentration used; isotonic saline caused similar obstruction but not a complete cessation of peripheral airflows. The baseline oxygen saturation was significantly correlated with the fall in lung function. Ten minutes after inhalation lung function tests returned to baseline values. CONCLUSION: As salbutamol could significantly reduce airway obstruction tobramycin should always be inhaled in combination with a bronchodilator.
UNLABELLED: To assess the airway response to inhaled tobramycin we measured flow volume curves in 12 patients with cystic fibrosis. Immediately and/or 2 min after tobramycin inhalations there was a significant fall in lung function regardless of the concentration used; isotonic saline caused similar obstruction but not a complete cessation of peripheral airflows. The baseline oxygen saturation was significantly correlated with the fall in lung function. Ten minutes after inhalation lung function tests returned to baseline values. CONCLUSION: As salbutamol could significantly reduce airway obstructiontobramycin should always be inhaled in combination with a bronchodilator.
Authors: B W Ramsey; H L Dorkin; J D Eisenberg; R L Gibson; I R Harwood; R M Kravitz; D V Schidlow; R W Wilmott; S J Astley; M A McBurnie Journal: N Engl J Med Date: 1993-06-17 Impact factor: 91.245
Authors: Timothy P Gauthier; Justin Wasko; Nathan R Unger; Lilian M Abbo; Margaret Fernandez; Laura Aragon Journal: Antibiotics (Basel) Date: 2015-12-29