BACKGROUND: The apolipoprotein E (ApoE) epsilon 4 allele is associated with an increased risk of senile and probably presenile Alzheimer's disease. It is not yet clear whether the epsilon 4 allele also influences the duration/rate of progress of illness and the severity of the dementia. METHOD: We have retrospectively examined a series of ApoE genotyped presenile and senile autopsy cases of Alzheimer's disease (AD) for length of illness and severity of pathology. RESULTS: We find no evidence that ApoE genotype affects the rate of progress of AD, but the degree of pathology at death may be increased. CONCLUSION: It appears that the rate of progress of AD as a whole is independent of the ApoE genotype.
BACKGROUND: The apolipoprotein E (ApoE) epsilon 4 allele is associated with an increased risk of senile and probably presenile Alzheimer's disease. It is not yet clear whether the epsilon 4 allele also influences the duration/rate of progress of illness and the severity of the dementia. METHOD: We have retrospectively examined a series of ApoE genotyped presenile and senile autopsy cases of Alzheimer's disease (AD) for length of illness and severity of pathology. RESULTS: We find no evidence that ApoE genotype affects the rate of progress of AD, but the degree of pathology at death may be increased. CONCLUSION: It appears that the rate of progress of AD as a whole is independent of the ApoE genotype.
Authors: H Bickeböller; D Campion; A Brice; P Amouyel; D Hannequin; O Didierjean; C Penet; C Martin; J Pérez-Tur; A Michon; B Dubois; F Ledoze; C Thomas-Anterion; F Pasquier; M Puel; J F Demonet; O Moreaud; M C Babron; D Meulien; D Guez; M C Chartier-Harlin; T Frebourg; Y Agid; M Martinez; F Clerget-Darpoux Journal: Am J Hum Genet Date: 1997-02 Impact factor: 11.025
Authors: Kelly L Lange; Mark W Bondi; David P Salmon; Douglas Galasko; Dean C Delis; Ronald G Thomas; Leon J Thal Journal: J Int Neuropsychol Soc Date: 2002-11 Impact factor: 2.892
Authors: Mark W Bondi; Wes S Houston; David P Salmon; Jody Corey-Bloom; Robert Katzman; Leon J Thal; Dean C Delis Journal: J Int Neuropsychol Soc Date: 2003-07 Impact factor: 2.892