BACKGROUND: Overexpression of cyclin D1 and p53 protein has been reported in many types of malignant tumors. OBJECTIVES: We investigated whether cyclin D1 was detected immunohistochemically in various types of malignant tumors of the skin, comparable with p53 protein. METHODS: Immunohistochemical staining of cyclin D1 and p53 protein was applied to squamous cell carcinoma, malignant melanoma and malignant fibrous histiocytoma and various kinds of benign skin tumors. RESULTS: Cyclin D1 was positive only in malignant tumors at the same incidence as p53 protein. CONCLUSION: Cyclin D1 immunohistochemical staining may be a malignant marker for various skin tumors.
BACKGROUND: Overexpression of cyclin D1 and p53 protein has been reported in many types of malignant tumors. OBJECTIVES: We investigated whether cyclin D1 was detected immunohistochemically in various types of malignant tumors of the skin, comparable with p53 protein. METHODS: Immunohistochemical staining of cyclin D1 and p53 protein was applied to squamous cell carcinoma, malignant melanoma and malignant fibrous histiocytoma and various kinds of benign skin tumors. RESULTS:Cyclin D1 was positive only in malignant tumors at the same incidence as p53 protein. CONCLUSION:Cyclin D1 immunohistochemical staining may be a malignant marker for various skin tumors.
Authors: Corina Kaufmann; Werner Kempf; Joanna Mangana; Phil Cheng; Michael Emberger; Roland Lang; Andreas K Kaiser; Evelyn Lattmann; Mitchell Levesque; Reinhard Dummer; Peter Koelblinger Journal: Histopathology Date: 2020-07-04 Impact factor: 5.087