Safety and side effects of i.v. immunoglobulin therapy.

The safety of i.v. immunoglobulin therapy, as compared to other therapeutic measures used in modern medicine today, is rather good. However, a number of side effects may become serious in patients at risk. Thanks to over 20 years of experience with i.v. immunoglobulins, we hope to soon be able to draw up a nearly complete list of potential side effects. In fact, knowledge of the possible side effects is essential when it comes to their prevention. The elderly, patients with kidney disease and arteriosclerotic patients, as well as IgA deficient recipients, are at risk, but may well receive i.v. immunoglobulins if certain prophylactic measures are taken or if the infusion speed and/or the total dosage given are properly adjusted. This article will deal with the major side effects of i.v. immunoglobulin therapy and their prevention.