A C Sciscione1, R Gorman, N A Callan. 1. Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Abstract
OBJECTIVE: Birth weight is a function of gestational age. Various maternal and infant characteristics also affect birth weight. This study sought to adjust for these factors to better define abnormal growth. STUDY DESIGN: Maternal and infant characteristics from normal pregnancies were correlated with birth weight. A formula was developed and applied to a second group in which we compared perinatal outcomes in normally grown infants with those who were small for gestational age. We compared outcomes between small-for-gestational-age infants defined by the formula with those defined by conventional tables. RESULTS: Infants defined by the formula as small-for-gestational-age were more likely to have morbidity and mortality than those who were normally grown (p < 0.001). Small-for-gestational-age infants defined by the formula had more deaths and adverse outcomes than those defined by gestational age. CONCLUSION: Adjusting birth weight standards for maternal and infant characteristics may improve the prediction of adverse outcomes.
OBJECTIVE: Birth weight is a function of gestational age. Various maternal and infant characteristics also affect birth weight. This study sought to adjust for these factors to better define abnormal growth. STUDY DESIGN: Maternal and infant characteristics from normal pregnancies were correlated with birth weight. A formula was developed and applied to a second group in which we compared perinatal outcomes in normally grown infants with those who were small for gestational age. We compared outcomes between small-for-gestational-age infants defined by the formula with those defined by conventional tables. RESULTS:Infants defined by the formula as small-for-gestational-age were more likely to have morbidity and mortality than those who were normally grown (p < 0.001). Small-for-gestational-age infants defined by the formula had more deaths and adverse outcomes than those defined by gestational age. CONCLUSION: Adjusting birth weight standards for maternal and infant characteristics may improve the prediction of adverse outcomes.
Authors: Maged M Costantine; Yinglei Lai; Steven L Bloom; Catherine Y Spong; Michael W Varner; Dwight J Rouse; Susan M Ramin; Steve N Caritis; Alan M Peaceman; Yoram Sorokin; Anthony Sciscione; Brian M Mercer; John M Thorp; Fergal D Malone; Margaret Harper; Jay D Iams Journal: Am J Perinatol Date: 2012-08-14 Impact factor: 1.862