Literature DB >> 8826859

Independent prognostic value of preoperative serum markers CA 242, specific tissue polypeptide antigen and human chorionic gonadotrophin beta, but not of carcinoembryonic antigen or tissue polypeptide antigen in colorectal cancer.

M Carpelan-Holmström1, C Haglund, J Lundin, H Alfthan, U H Stenman, P J Roberts.   

Abstract

The prognostic value of preoperative serum concentrations of carcinoembryonic antigen (CEA), CA 242, tissue polypeptide antigen (TPA), specific tissue polypeptide antigen (TPS) and human chorionic gonadotrophin beta (hCG beta) in 251 patients with colorectal cancer (39 Dukes' A, 98 Dukes' B, 56 Dukes' C and 58 Dukes' D) was investigated. When using the cut-off levels recommended for diagnostic purposes, there was a significantly longer overall survival in patients with low tumour marker levels compared with patients with elevated serum levels for all the investigated markers. In Dukes' stage B, C and D CA 242 emerged as a significant predictor of survival, whereas TPA, TPS and hCG beta showed a value only in Dukes' D. Unfortunately, no marker provided prognostic information in Dukes' A. In multivariate analysis, entering the tumour markers as continuous variables, Dukes' stage was the strongest prognostic factor, followed by CA 242. TPS, hCG beta and localisation of the tumour were also independent prognostic factors, whereas age, gender, CEA and TPA were not.

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Year:  1996        PMID： 8826859      PMCID： PMC2074725          DOI： 10.1038/bjc.1996.458

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  24 in total

1.  Regression analysis of prognostic factors in colorectal cancer after curative resections.

Authors:  T Wiggers; J W Arends; A Volovics
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2.  Prognostic value of CA 19.9 levels in colorectal cancer.

Authors:  X Filella; R Molina; J J Grau; J M Piqué; J C Garcia-Valdecasas; E Astudillo; A Biete; J M Bordas; A Novell; E Campo
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Authors:  N Wolmark; B Fisher; H S Wieand; R S Henry; H Lerner; S Legault-Poisson; P J Deckers; N Dimitrov; P H Gordon; P Jochimsen
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4.  Prognostic value of preoperative serum CEA level compared to clinical staging. IV. Histological grading and tumor type in colorectal and gastric cancer.

Authors:  O Bogenschütz; T Brümmendorf; H J Staab; F A Anderer; G Kieninger
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Authors:  C G Moertel; J R O'Fallon; V L Go; M J O'Connell; G S Thynne
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6.  Preoperative serum markers in carcinoma of the rectum and rectosigmoid. I. Prediction of tumour stage.

Authors:  E Ståhle; B Glimelius; R Bergström; L Påhlman
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Authors:  E Ståhle; B Glimelius; R Bergström; L Påhlman
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Authors:  T Brümmendorf; F A Anderer; H J Staab; A Hornung; E Stumpf; G Kieninger
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Authors:  P Kuusela; C Haglund; P J Roberts
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