Literature DB >> 8826462

Regional localization of two MRX genes to Xq28 (MRX28) and to Xp11.4-Xp22.12 (MRX33).

E Holinski-Feder1, A Golla, I Rost, H Seidel, O Rittinger, A Meindl.   

Abstract

Two genes responsible for a nonspecific form of X-linked mental retardation (MRX28 and MRX33) were localized by linkage analysis with 40 highly polymorphic DNA markers situated along the entire the X chromosome. In family 1, the gene could be mapped within a 14-cM interval at Xq28, distal to the recombining marker DXS1113 (MRX28). The maximum LOD score was 2.75, with DXS52 at phi = .0. In family 2, the gene was localized within a 30-cM interval at Xp11.4-22.12 between the recombining markers DXS365 and MAOB, including the DMD gene (MRX33). Maximum LOD scores of 2.82 were obtained with markers DMD-STR49, DMD-DysII, CYBB, and DXS1068.

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Year:  1996        PMID： 8826462     DOI： 10.1002/(SICI)1096-8628(19960712)64:1<125::AID-AJMG21>3.0.CO;2-O

Source DB:  PubMed          Journal:  Am J Med Genet        ISSN： 0148-7299


  5 in total

1.  Deletion mapping and X inactivation analysis of a non-specific mental retardation gene at Xp21.3-Xp22.11.

Authors:  K Muroya; E Kinoshita; T Kamimaki; N Matsuo; T Yorifugi; T Ogata
Journal:  J Med Genet       Date:  1999-03       Impact factor: 6.318

2.  A new X linked recessive syndrome of mental retardation and mild dysmorphism maps to Xq28.

Authors:  G S Pai; B Hane; M Joseph; R Nelson; L S Hammond; J F Arena; H A Lubs; R E Stevenson; C E Schwartz
Journal:  J Med Genet       Date:  1997-07       Impact factor: 6.318

3.  A gene for dominant nonspecific X-linked mental retardation is located in Xq28.

Authors:  V des Portes; P Billuart; A Carrié; L Bachner; T Bienvenu; M C Vinet; C Beldjord; G Ponsot; A Kahn; J Boué; J Chelly
Journal:  Am J Hum Genet       Date:  1997-04       Impact factor: 11.025

4.  Identification of a 650 kb duplication at the X chromosome breakpoint in a patient with 46,X,t(X;8)(q28;q12) and non-syndromic mental retardation.

Authors:  J J Cox; S T Holden; S Dee; J I Burbridge; F L Raymond
Journal:  J Med Genet       Date:  2003-03       Impact factor: 6.318

5.  XLMR in MRX families 29, 32, 33 and 38 results from the dup24 mutation in the ARX (Aristaless related homeobox) gene.

Authors:  Monica L Stepp; A Lauren Cason; Merran Finnis; Marie Mangelsdorf; Elke Holinski-Feder; David Macgregor; Andrée MacMillan; Jeanette J A Holden; Jozef Gecz; Roger E Stevenson; Charles E Schwartz
Journal:  BMC Med Genet       Date:  2005-04-25       Impact factor: 2.103
  5 in total

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