Literature DB >> 8825930

A large multisite cancer family is linked to BRCA2.

P Tonin1, P Ghadirian, C Phelan, G M Lenoir, H T Lynch, F Letendre, D Belanger, M Monté, S A Narod.   

Abstract

We identified a large French-Canadian family with 21 cases of breast cancer, including two affected brothers. Segregation of markers from chromosome 13q in this family showed linkage to the BRCA2 gene locus (lod = 3.67 at D13S289). A number of cancers of other types occurred in this family, including three cases of prostate cancer and two cases of lymphoma. The penetrance of breast cancer among BRCA2 carriers is estimated to be 75% to the age of 70.

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Year:  1995        PMID： 8825930      PMCID： PMC1051783          DOI： 10.1136/jmg.32.12.982

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  6 in total

1.  Hereditary breast cancer in 19 females and 2 males: Kindred, P.G. 1940.

Authors:  P Ghadirian; S Narod; C Perret; D M Lambert; J Latreille; F Letendre; M Monté; D Belanger
Journal:  Eur J Cancer       Date:  1995       Impact factor: 9.162

2.  Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13.

Authors:  R Wooster; S L Neuhausen; J Mangion; Y Quirk; D Ford; N Collins; K Nguyen; S Seal; T Tran; D Averill
Journal:  Science       Date:  1994-09-30       Impact factor: 47.728

3.  A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

Authors:  Y Miki; J Swensen; D Shattuck-Eidens; P A Futreal; K Harshman; S Tavtigian; Q Liu; C Cochran; L M Bennett; W Ding
Journal:  Science       Date:  1994-10-07       Impact factor: 47.728

4.  Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families.

Authors:  J Simard; P Tonin; F Durocher; K Morgan; J Rommens; S Gingras; C Samson; J F Leblanc; C Bélanger; F Dion
Journal:  Nat Genet       Date:  1994-12       Impact factor: 38.330

5.  An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Breast Cancer Linkage Consortium.

Authors:  S A Narod; D Ford; P Devilee; R B Barkardottir; H T Lynch; S A Smith; B A Ponder; B L Weber; J E Garber; J M Birch
Journal:  Am J Hum Genet       Date:  1995-01       Impact factor: 11.025

6.  Familial male breast cancer is not linked to the BRCA1 locus on chromosome 17q.

Authors:  M R Stratton; D Ford; S Neuhasen; S Seal; R Wooster; L S Friedman; M C King; V Egilsson; P Devilee; R McManus
Journal:  Nat Genet       Date:  1994-05       Impact factor: 38.330
  6 in total
  8 in total

1.  Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells.

Authors:  J V Rajan; M Wang; S T Marquis; L A Chodosh
Journal:  Proc Natl Acad Sci U S A       Date:  1996-11-12       Impact factor: 11.205

2.  Variation in cancer risks, by mutation position, in BRCA2 mutation carriers.

Authors:  D Thompson; D Easton
Journal:  Am J Hum Genet       Date:  2001-01-19       Impact factor: 11.025

Review 3.  Pancreatic adenocarcinoma: epidemiology and genetics.

Authors:  T Y Flanders; W D Foulkes
Journal:  J Med Genet       Date:  1996-11       Impact factor: 6.318

4.  Increased incidence of cancer in first degree relatives of women with double primary carcinomas of the breast and colon.

Authors:  W D Foulkes; N Bolduc; D Lambert; O Ginsburg; L Olien; D W Yandell; P N Tonin; S A Narod
Journal:  J Med Genet       Date:  1996-07       Impact factor: 6.318

5.  Contribution of the Defective BRCA1, BRCA2 and CHEK2 Genes to the Familial Aggregation of Breast Cancer: a Simulation Study Based on the Swedish Family-Cancer Database.

Authors:  Justo Lorenzo Bermejo; Alfonso García Pérez; Kari Hemminki
Journal:  Hered Cancer Clin Pract       Date:  2004-11-15       Impact factor: 2.857

6.  Prolactin levels, breast-feeding and milk production in a cohort of young healthy women from high-risk breast cancer families: implications for breast cancer risk.

Authors:  Maria Hietala; Håkan Olsson; Helena Jernström
Journal:  Fam Cancer       Date:  2007-12-15       Impact factor: 2.375

Review 7.  The Role of BRCA2 Mutation Status as Diagnostic, Predictive, and Prognosis Biomarker for Pancreatic Cancer.

Authors:  Javier Martinez-Useros; Jesus Garcia-Foncillas
Journal:  Biomed Res Int       Date:  2016-12-18       Impact factor: 3.411

8.  Insulin-like growth factor-1 (IGF1) genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating IGF-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer families.

Authors:  H Jernström; T Sandberg; E Bågeman; A Borg; H Olsson
Journal:  Br J Cancer       Date:  2005-03-14       Impact factor: 7.640
  8 in total

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