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Literature DB >> 8825117

Recombinant immunotoxins.

I Pastan¹, L H Pai, U Brinkmann, D FitzGerald.

Abstract

Pseudomonas exotoxin has been genetically modified so that it targets cancer cells. This was accomplished by deleting its cell binding domain and replacing it with Fv fragments of antibodies that react with breast, colon, and other cancers. Several recombinant immunotoxins are now in clinical trials.

Entities: Chemical

Mesh：

Substances：

Year: 1996 PMID： 8825117 DOI： 10.1007/BF01803778

Source DB: PubMed Journal: Breast Cancer Res Treat ISSN： 0167-6806 Impact factor: 4.624

25 in total

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3 in total

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Authors: M D Sheets; P Amersdorfer; R Finnern; P Sargent; E Lindquist; R Schier; G Hemingsen; C Wong; J C Gerhart; J D Marks; E Lindqvist
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3 in total