Literature DB >> 8825083

Immunological and functional characterization of Mycobacterium leprae protein antigens: an overview.

J E Thole1, B Wieles, J E Clark-Curtiss, T H Ottenhoff, T F Rinke de Wit.   

Abstract

A major focus of leprosy research in the last 10 years has been the identification and characterization of antigens of Mycobacterium leprae that interact with antibodies and T cells of the host's immune response. Through the combined efforts of many different laboratories, a substantial number of protein antigens have been identified and characterized. In this MicroReview we present an updated list of M. leprae protein antigens, and, with emphasis on recent developments, summarize what is known regarding their functional and immunological features.

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Year:  1995        PMID： 8825083     DOI： 10.1111/j.1365-2958.1995.18050791.x

Source DB:  PubMed          Journal:  Mol Microbiol        ISSN： 0950-382X            Impact factor:   3.501


  12 in total

1.  Presence of human T-cell responses to the Mycobacterium leprae 45-kilodalton antigen reflects infection with or exposure to M. leprae.

Authors:  A Macfarlane; R Mondragon-Gonzalez; F Vega-Lopez; B Wieles; J de Pena; O Rodriguez; R Suarez y de la Torre; R R de Vries; T H Ottenhoff; H M Dockrell
Journal:  Clin Diagn Lab Immunol       Date:  2001-05

2.  Molecular and immunological analyses of the Mycobacterium avium homolog of the immunodominant Mycobacterium leprae 35-kilodalton protein.

Authors:  J A Triccas; N Winter; P W Roche; A Gilpin; K E Kendrick; W J Britton
Journal:  Infect Immun       Date:  1998-06       Impact factor: 3.441

3.  Human T cell responses to peptides of the Mycobacterium leprae 45-kD serine-rich antigen.

Authors:  S Brahmbhatt; R Hussain; S Zafar; G Dawood; T H M Ottenhoff; J W Drijfhout; G Bothamley; S Smith; F V Lopez; H M Dockrell
Journal:  Clin Exp Immunol       Date:  2002-04       Impact factor: 4.330

4.  Immunohistological analysis of in situ expression of mycobacterial antigens in skin lesions of leprosy patients across the histopathological spectrum. Association of Mycobacterial lipoarabinomannan (LAM) and Mycobacterium leprae phenolic glycolipid-I (PGL-I) with leprosy reactions.

Authors:  C Verhagen; W Faber; P Klatser; A Buffing; B Naafs; P Das
Journal:  Am J Pathol       Date:  1999-06       Impact factor: 4.307

5.  A 21-kDa surface protein of Mycobacterium leprae binds peripheral nerve laminin-2 and mediates Schwann cell invasion.

Authors:  Y Shimoji; V Ng; K Matsumura; V A Fischetti; A Rambukkana
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

6.  Molecular definition and identification of new proteins of Mycobacterium leprae.

Authors:  M C Pessolani; P J Brennan
Journal:  Infect Immun       Date:  1996-12       Impact factor: 3.441

Review 7.  The continuing challenges of leprosy.

Authors:  D M Scollard; L B Adams; T P Gillis; J L Krahenbuhl; R W Truman; D L Williams
Journal:  Clin Microbiol Rev       Date:  2006-04       Impact factor: 26.132

8.  Gamma interferon responses induced by a panel of recombinant and purified mycobacterial antigens in healthy, non-mycobacterium bovis BCG-vaccinated Malawian young adults.

Authors:  Gillian F Black; Rosemary E Weir; Steven D Chaguluka; David Warndorff; Amelia C Crampin; Lorren Mwaungulu; Lifted Sichali; Sian Floyd; Lyn Bliss; Elizabeth Jarman; Linda Donovan; Peter Andersen; Warwick Britton; Glyn Hewinson; Kris Huygen; Jens Paulsen; Mahavir Singh; Ross Prestidge; Paul E M Fine; Hazel M Dockrell
Journal:  Clin Diagn Lab Immunol       Date:  2003-07

9.  Multiple Mycobacterium antigens induce interferon-gamma production from sarcoidosis peripheral blood mononuclear cells.

Authors:  J Carlisle; W Evans; R Hajizadeh; M Nadaf; B Shepherd; R D Ott; K Richter; W Drake
Journal:  Clin Exp Immunol       Date:  2007-10-09       Impact factor: 4.330

10.  Specificity and function of immunogenic peptides from the 35-kilodalton protein of Mycobacterium leprae.

Authors:  R J Wilkinson; K A Wilkinson; S Jurcevic; A Hills; S Sinha; U Sengupta; D N Lockwood; K Katoch; D Altman; J Ivanyi
Journal:  Infect Immun       Date:  1999-03       Impact factor: 3.441
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