Literature DB >> 8824640

The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment.

W Siede1, J B Allen, S J Elledge, E C Friedberg.   

Abstract

The Saccharomyces cerevisiae gene MEC1 represents a structural homolog of the human gene ATM mutated in ataxia telangiectasia patients. Like human ataxia telangiectasia cell lines, mec1 mutants are defective in G2 and S-phase cell cycle checkpoints in response to radiation treatment. Here we show an additional defect in G1 arrest following treatment with UV light or gamma rays and map a defective arrest stage at or upstream of START in the yeast cell cycle.

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Year:  1996        PMID： 8824640      PMCID： PMC178434          DOI： 10.1128/jb.178.19.5841-5843.1996

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  23 in total

1.  Detection of ataxia telangiectasia heterozygous cell lines by postirradiation cumulative labeling index: measurements with coded samples.

Authors:  H Nagasawa; K H Kraemer; Y Shiloh; J B Little
Journal:  Cancer Res       Date:  1987-01-15       Impact factor: 12.701

2.  Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

Authors:  T Juven; Y Barak; A Zauberman; D L George; M Oren
Journal:  Oncogene       Date:  1993-12       Impact factor: 9.867

3.  Radiosensitivity in ataxia-telangiectasia: a new explanation.

Authors:  R B Painter; B R Young
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

4.  The role of the Ataxia telangiectasia gene in the p53, WAF1/CIP1(p21)- and GADD45-mediated response to DNA damage produced by ionising radiation.

Authors:  M Artuso; A Esteve; H Brésil; M Vuillaume; J Hall
Journal:  Oncogene       Date:  1995-10-19       Impact factor: 9.867

5.  Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.

Authors:  T A Weinert; G L Kiser; L H Hartwell
Journal:  Genes Dev       Date:  1994-03-15       Impact factor: 11.361

6.  The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.

Authors:  C E Canman; A C Wolff; C Y Chen; A J Fornace; M B Kastan
Journal:  Cancer Res       Date:  1994-10-01       Impact factor: 12.701

7.  The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast.

Authors:  J B Allen; Z Zhou; W Siede; E C Friedberg; S J Elledge
Journal:  Genes Dev       Date:  1994-10-15       Impact factor: 11.361

8.  p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

Authors:  V Dulić; W K Kaufmann; S J Wilson; T D Tlsty; E Lees; J W Harper; S J Elledge; S I Reed
Journal:  Cell       Date:  1994-03-25       Impact factor: 41.582

9.  An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae.

Authors:  R Kato; H Ogawa
Journal:  Nucleic Acids Res       Date:  1994-08-11       Impact factor: 16.971

10.  Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

Authors:  X Lu; D P Lane
Journal:  Cell       Date:  1993-11-19       Impact factor: 41.582
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  23 in total

1.  Replication protein A is sequentially phosphorylated during meiosis.

Authors:  G S Brush; D M Clifford; S M Marinco; A J Bartrand
Journal:  Nucleic Acids Res       Date:  2001-12-01       Impact factor: 16.971

2.  Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response.

Authors:  G S Brush; T J Kelly
Journal:  Nucleic Acids Res       Date:  2000-10-01       Impact factor: 16.971

3.  The yeast TEL1 gene partially substitutes for human ATM in suppressing hyperrecombination, radiation-induced apoptosis and telomere shortening in A-T cells.

Authors:  E Fritz; A A Friedl; R M Zwacka; F Eckardt-Schupp; M S Meyn
Journal:  Mol Biol Cell       Date:  2000-08       Impact factor: 4.138

4.  An essential role for the Saccharomyces cerevisiae DEAD-box helicase DHH1 in G1/S DNA-damage checkpoint recovery.

Authors:  Megan Bergkessel; Joseph C Reese
Journal:  Genetics       Date:  2004-05       Impact factor: 4.562

5.  Evidence of meiotic crossover control in Saccharomyces cerevisiae through Mec1-mediated phosphorylation of replication protein A.

Authors:  Amy J Bartrand; Dagmawi Iyasu; Suzanne M Marinco; George S Brush
Journal:  Genetics       Date:  2005-08-22       Impact factor: 4.562

6.  The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast.

Authors:  M P Longhese; V Paciotti; R Fraschini; R Zaccarini; P Plevani; G Lucchini
Journal:  EMBO J       Date:  1997-09-01       Impact factor: 11.598

7.  Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79.

Authors:  Danielle Tatum; Shisheng Li
Journal:  J Biol Chem       Date:  2011-04-01       Impact factor: 5.157

8.  Tof1p regulates DNA damage responses during S phase in Saccharomyces cerevisiae.

Authors:  E J Foss
Journal:  Genetics       Date:  2001-02       Impact factor: 4.562

9.  Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptor.

Authors:  Randal A Hand; Nan Jia; Martin Bard; Rolf J Craven
Journal:  Eukaryot Cell       Date:  2003-04

10.  A role for checkpoint kinase-dependent Rad26 phosphorylation in transcription-coupled DNA repair in Saccharomyces cerevisiae.

Authors:  Michael Taschner; Michelle Harreman; Yumin Teng; Hefin Gill; Roy Anindya; Sarah L Maslen; J Mark Skehel; Raymond Waters; Jesper Q Svejstrup
Journal:  Mol Cell Biol       Date:  2009-11-09       Impact factor: 4.272
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