Literature DB >> 8824357

Phase II trial of edatrexate in patients with metastatic colorectal cancer.

G H Clamon1, C E Riggs, R Dreicer, R J Hohl.   

Abstract

Edatrexate is an analog of methotrexate which in vitro demonstrated activity against human colon cancer xenografts grown in nude mice. In a phase II trial, 12 patients with metastatic colorectal cancer and no prior chemotherapy were treated with Edatrexate 80 mg/m2/week for an initial period of 8 weeks. No objective responses were observed. Edatrexate is inactive against colon cancer at the dose and schedule used in this trial.

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Year:  1996        PMID： 8824357     DOI： 10.1007/bf00873145

Source DB:  PubMed          Journal:  Invest New Drugs        ISSN： 0167-6997            Impact factor:   3.850


  7 in total

1.  Comparison of antimetabolites in the treatment of breast and colon cancer.

Authors: 
Journal:  JAMA       Date:  1967-05-29       Impact factor: 56.272

2.  Sequential methotrexate and 5-fluorouracil: improved response rate in metastatic colorectal cancer.

Authors:  R Herrmann; J Spehn; J H Beyer; U von Franqué; A Schmieder; K Holzmann; U Abel
Journal:  J Clin Oncol       Date:  1984-06       Impact factor: 44.544

3.  New folate analogs of the 10-deaza-aminopterin series. Basis for structural design and biochemical and pharmacologic properties.

Authors:  F M Sirotnak; J I DeGraw; D M Moccio; L L Samuels; L J Goutas
Journal:  Cancer Chemother Pharmacol       Date:  1984       Impact factor: 3.333

4.  New folate analogs of the 10-deaza-aminopterin series. Further evidence for markedly increased antitumor efficacy compared with methotrexate in ascitic and solid murine tumor models.

Authors:  F M Sirotnak; J I DeGraw; F A Schmid; L J Goutas; D M Moccio
Journal:  Cancer Chemother Pharmacol       Date:  1984       Impact factor: 3.333

5.  New folate analogs of the 10-deaza-aminopterin series: markedly increased antitumor activity of the 10-ethyl analog compared to the parent compound and methotrexate against some human tumor xenografts in nude mice.

Authors:  F A Schmid; F M Sirotnak; G M Otter; J I DeGraw
Journal:  Cancer Treat Rep       Date:  1985-05

6.  Sequential therapy with methotrexate and 5-fluorouracil in the treatment of advanced colorectal carcinoma.

Authors:  B A Leone; A Romero; M G Rabinovich; J E Perez; M Macchiavelli; E Strauss
Journal:  J Clin Oncol       Date:  1986-01       Impact factor: 44.544

7.  Phase II trial of 10-Edam in patients with advanced colorectal carcinoma.

Authors:  N Kemeny; K Israel; M O'Hehir
Journal:  Am J Clin Oncol       Date:  1990-02       Impact factor: 2.339
  7 in total
  1 in total

Review 1.  From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates.

Authors:  Jackie Walling
Journal:  Invest New Drugs       Date:  2006-01       Impact factor: 3.651
  1 in total

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