PURPOSE: A phase II trial of topotecan, an inhibitor of topoisomerase I, was conducted in patients with advanced or metastatic adenocarcinoma of the pancreas to determine the activity and toxicity of topotecan. PATIENTS AND MATERIALS: 35 patients, previously untreated with chemotherapy, received topotecan 1.5 mg/m2/d for five days intravenously and repeated every 21 days. Patients were assessed for response after 3 cycles. Those with either clinical response or stable disease received additional cycles of the drug until toxicity developed or disease progression occurred. RESULTS: Among 30 patients evaluable for response there were no complete responses and 3 partial responses (10%) for a total response rate of 10% (95% confidence interval = 0-20.6%). Stable disease for at least eight weeks was seen in 11 patients (36%). Median survival was 19 weeks (95% confidence interval 11 to 26 weeks). Therapy was generally well tolerated, with reversible granulocytopenia being the most common toxicity. CONCLUSION: Topotecan given on a 5 day, short infusion schedule, demonstrated limited activity in pancreatic carcinoma with minimal toxicity. Further exploration of topotecan in pancreatic carcinoma using different dosing schedules is warranted.
PURPOSE: A phase II trial of topotecan, an inhibitor of topoisomerase I, was conducted in patients with advanced or metastatic adenocarcinoma of the pancreas to determine the activity and toxicity of topotecan. PATIENTS AND MATERIALS: 35 patients, previously untreated with chemotherapy, received topotecan 1.5 mg/m2/d for five days intravenously and repeated every 21 days. Patients were assessed for response after 3 cycles. Those with either clinical response or stable disease received additional cycles of the drug until toxicity developed or disease progression occurred. RESULTS: Among 30 patients evaluable for response there were no complete responses and 3 partial responses (10%) for a total response rate of 10% (95% confidence interval = 0-20.6%). Stable disease for at least eight weeks was seen in 11 patients (36%). Median survival was 19 weeks (95% confidence interval 11 to 26 weeks). Therapy was generally well tolerated, with reversible granulocytopenia being the most common toxicity. CONCLUSION:Topotecan given on a 5 day, short infusion schedule, demonstrated limited activity in pancreatic carcinoma with minimal toxicity. Further exploration of topotecan in pancreatic carcinoma using different dosing schedules is warranted.
Authors: B C Giovanella; J S Stehlin; M E Wall; M C Wani; A W Nicholas; L F Liu; R Silber; M Potmesil Journal: Science Date: 1989-11-24 Impact factor: 47.728
Authors: L Saltz; M Sirott; C Young; W Tong; D Niedzwiecki; Y Tzy-Jyun; Y Tao; B Trochanowski; P Wright; K Barbosa Journal: J Natl Cancer Inst Date: 1993-09-15 Impact factor: 13.506
Authors: W D Kingsbury; J C Boehm; D R Jakas; K G Holden; S M Hecht; G Gallagher; M J Caranfa; F L McCabe; L F Faucette; R K Johnson Journal: J Med Chem Date: 1991-01 Impact factor: 7.446
Authors: H A Burris; A R Hanauske; R K Johnson; M H Marshall; J G Kuhn; S G Hilsenbeck; D D Von Hoff Journal: J Natl Cancer Inst Date: 1992-12-02 Impact factor: 13.506
Authors: M L Rothenberg; J G Kuhn; H A Burris; J Nelson; J R Eckardt; M Tristan-Morales; S G Hilsenbeck; G R Weiss; L S Smith; G I Rodriguez Journal: J Clin Oncol Date: 1993-11 Impact factor: 44.544
Authors: E K Rowinsky; L B Grochow; C B Hendricks; D S Ettinger; A A Forastiere; L A Hurowitz; W P McGuire; S E Sartorius; B G Lubejko; S H Kaufmann Journal: J Clin Oncol Date: 1992-04 Impact factor: 44.544
Authors: N Masuda; M Fukuoka; S Kudoh; K Matsui; Y Kusunoki; M Takada; K Nakagawa; T Hirashima; H Tsukada; T Yana Journal: J Clin Oncol Date: 1994-09 Impact factor: 44.544
Authors: S Cascinu; R R Silva; S Barni; R Labianca; L Frontini; E Piazza; G Pancera; P Giordani; L Giuliodori; M A Pessi; V Fusco; G Luporini; R Cellerino; G Catalano Journal: Br J Cancer Date: 1999-07 Impact factor: 7.640
Authors: G P Stathopoulos; K Syrigos; G Aravantinos; A Polyzos; P Papakotoulas; G Fountzilas; A Potamianou; N Ziras; J Boukovinas; J Varthalitis; N Androulakis; A Kotsakis; G Samonis; V Georgoulias Journal: Br J Cancer Date: 2006-08-08 Impact factor: 7.640