Literature DB >> 882155

Taurolithocholate inhibits taurocholate uptake by isolated hepatocytes at low concentrations.

M Schwenk, L R Schwarz, H Greim.   

Abstract

The cholestatic bile acid taurolithocholate inhibits taurocholate uptake by isolated liver cells non-competitively. Inhibition is instantaneous and inversely related to the cell number in the incubate. The Ki amounts to 7 micron in the presence of 2 mg cellular protein per ml. Secretion of taurocholate by isolated liver cells is not affected by taurolithocholate up to a concentration of 50 micron. This indicates a difference between the carrier for taurocholate uptake and the carrier for taurocholate secretion. Inhibition of bile acid uptake of liver cells may be involved in the pathogenesis of lithocholate-induced cholestasis.

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Year:  1977        PMID： 882155     DOI： 10.1007/bf00508626

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  8 in total

1.  Uptake of taurocholic acid into isolated rat-liver cells.

Authors:  L R Schwarz; R Burr; M Schwenk; E Pfaff; H Greim
Journal:  Eur J Biochem       Date:  1975-07-15

2.  Effects of phospholipid acyl chain fluidity, phase transitions, and cholesterol on (Na+ + K+)-stimulated adenosine triphosphatase.

Authors:  H K Kimelberg; D Papahadjopoulos
Journal:  J Biol Chem       Date:  1974-02-25       Impact factor: 5.157

3.  Influence of bile salts on cholesterol synthesis in the isolated perfused rat liver.

Authors:  M E Liersch; C A Barth; H J Hackenschmidt; H L Ullmann; K F Decker
Journal:  Eur J Biochem       Date:  1973-01-15

4.  Biochemical and morphological parameters of taurolithocholate-induced cholestasis.

Authors:  B G Priestly; M G Côté; G L Plaa
Journal:  Can J Physiol Pharmacol       Date:  1971-12       Impact factor: 2.273

5.  Morphologic changes in hamster liver during intrahepatic cholestasis induced by taurolithocholate.

Authors:  F Schaffner; N B Javitt
Journal:  Lab Invest       Date:  1966-11       Impact factor: 5.662

6.  Lithocholate metabolism during chenotherapy for gallstone dissolution. 1. Serum levels of sulphated and unsulphated lithocholates.

Authors:  R N Allan; J L Thistle; A F Hofmann; J A Carter; P Y Yu
Journal:  Gut       Date:  1976-06       Impact factor: 23.059

7.  Acute cholestasis induced by lithocholic acid in the rat. A freeze-fracture replica and thin section study.

Authors:  K Miyal; W W Mayr; A L Richardson
Journal:  Lab Invest       Date:  1975-04       Impact factor: 5.662

8.  Cholestasis induced by sodium taurolithocholate in isolated hamster liver.

Authors:  J E King; L J Schoenfield
Journal:  J Clin Invest       Date:  1971-11       Impact factor: 14.808
  8 in total
  7 in total

1.  INTRACELLULAR SIGNALING BY BILE ACIDS.

Authors:  Mohammed Sawkat Anwer
Journal:  J Biosci (Rajshari)       Date:  2012

Review 2.  Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters.

Authors:  M Sawkat Anwer; Bruno Stieger
Journal:  Pflugers Arch       Date:  2013-10-03       Impact factor: 3.657

3.  Effects of taurolithocholate, a Ca2(+)-mobilizing agent, on cell Ca2(+) in rat hepatocytes, human platelets and neuroblastoma NG108-15 cell line.

Authors:  J F Coquil; B Berthon; N Chomiki; L Combettes; P Jourdon; C Schteingart; S Erlinger; M Claret
Journal:  Biochem J       Date:  1991-01-01       Impact factor: 3.857

4.  PKC{epsilon}-dependent and -independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in HuH-NTCP cell line.

Authors:  Christopher M Schonhoff; Ai Yamazaki; Simon Hohenester; Cynthia R L Webster; Bernard Bouscarel; M Sawkat Anwer
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2009-10-08       Impact factor: 4.052

5.  A compartmental model for hepatic transport of taurocholic acid in isolated perfused rat liver.

Authors:  R Kroker; M S Anwer; D Hegner
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-07       Impact factor: 3.000

6.  Effects of pentachlorophenol and 2,4,6-trichlorophenol on the disposition of sulfobromophthalein and respiration of isolated liver cells.

Authors:  R Götz; L R Schwarz; H Greim
Journal:  Arch Toxicol       Date:  1980-03       Impact factor: 5.153

7.  Natural bile acids and synthetic analogues modulate large conductance Ca2+-activated K+ (BKCa) channel activity in smooth muscle cells.

Authors:  Alejandro M Dopico; John V Walsh; Joshua J Singer
Journal:  J Gen Physiol       Date:  2002-03       Impact factor: 4.086
  7 in total

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