Literature DB >> 882148

The reversibility of the inhibition of intestinal amino-acid transport by harmaline.

M Buclon, F V Sepúlveda, J W Robinson.   

Abstract

The inhibitory aciton of harmaline on L-phenylalanine uptake by guinea-pig intestinal rings is fully reversible provided only low concentrations of the inhibitor are used; if the concentration is raised to a sufficient extent to enable the drug to interfere with sodium pumping or cellular metabolic reactions, as witnessed by its effect on tissue oxygen consumption, then the inhibition of L-phenylalanine uptake is only reversible if short contact times are employed.

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Year:  1977        PMID： 882148     DOI： 10.1007/bf00510987

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  8 in total

1.  ION MOVEMENTS AND OXYGEN CONSUMPTION IN KIDNEY CORTEX SLICES.

Authors:  R WHITTAM; J S WILLIS
Journal:  J Physiol       Date:  1963-08       Impact factor: 5.182

2.  Harmaline, a potent inhibitor of sodium-dependent transport.

Authors:  F V Sepúlveda; J W Robinson
Journal:  Biochim Biophys Acta       Date:  1974-12-24

3.  Harmaline: a competitive inhibitor of Na ion in the (Na+ + K+)-ATPase system.

Authors:  M Canessa; E Jaimovich; M de la Fuente
Journal:  J Membr Biol       Date:  1973-10-10       Impact factor: 1.843

4.  Comparative aspects of the response of the intestine to its ionic environment.

Authors:  J W Robinson
Journal:  Comp Biochem Physiol       Date:  1970-06-01

5.  The effects of harmaline on sodium transport in human erythrocytes: evidence in favor of action at interior sodium-sensitive sites.

Authors:  M J Dunn; W Hunt
Journal:  J Pharmacol Exp Ther       Date:  1975-06       Impact factor: 4.030

6.  New characteristics of harmaline inhibition of intestinal transport systems.

Authors:  F V Sepúlveda; J W Robinson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1975       Impact factor: 3.000

7.  Differential effects of harmaline and ouabain on intestinal sodium, phenylalanine and beta-methyl-glucoside transport.

Authors:  F V Sepúlveda; M Buclon; J W Robinson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-12       Impact factor: 3.000

8.  Effect of inhibitors on alanine transport in isolated rabbit ileum.

Authors:  R A Chez; R R Palmer; S G Schultz; P F Curran
Journal:  J Gen Physiol       Date:  1967-11       Impact factor: 4.086
  8 in total
  1 in total

1.  The effect of naringenin on the intestinal and renal transport of organic solutes.

Authors:  J W Robinson; M L'Herminier; H G Claudet
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-05       Impact factor: 3.000
  1 in total

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