Literature DB >> 8820571

Lymphocyte activation by CpG dinucleotide motifs in prokaryotic DNA.

A M Krieg1.   

Abstract

CpG dinucleotides are present at the expected frequency in prokaryotic DNA, but are underrepresented ('CpG suppression') and methylated in vertebrate DNA. The vertebrate immune system has apparently evolved the ability to recognize these unmethylated CpG motifs and respond with a rapid and coordinated cytokine response leading to the induction of humoral and cell-mediated immunity.

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Year:  1996        PMID： 8820571     DOI： 10.1016/0966-842X(96)81515-0

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  18 in total

Review 1.  Signal transduction induced by immunostimulatory CpG DNA.

Authors:  A M Krieg
Journal:  Springer Semin Immunopathol       Date:  2000

Review 2.  The role of immunostimulatory CpG-DNA in septic shock.

Authors:  H Wagner; G B Lipford; H Häcker
Journal:  Springer Semin Immunopathol       Date:  2000

3.  Correlation between anthrax lethal toxin neutralizing antibody levels and survival in guinea pigs and nonhuman primates vaccinated with the AV7909 anthrax vaccine candidate.

Authors:  Vladimir Savransky; Jeffry D Shearer; Melicia R Gainey; Daniel C Sanford; Gloria S Sivko; Gregory V Stark; Na Li; Boris Ionin; Michael J Lacy; Mario H Skiadopoulos
Journal:  Vaccine       Date:  2017-07-31       Impact factor: 3.641

4.  Epigenetic analysis of HIV-1 proviral genomes from infected individuals: predominance of unmethylated CpG's.

Authors:  Stefanie Weber; Barbara Weiser; Kimdar S Kemal; Harold Burger; Christina M Ramirez; Klaus Korn; Kathryn Anastos; Rupert Kaul; Colin Kovacs; Walter Doerfler
Journal:  Virology       Date:  2013-12-05       Impact factor: 3.616

5.  Unmethylated CpG-containing oligodeoxynucleotides inhibit apoptosis in WEHI 231 B lymphocytes induced by several agents: evidence for blockade of apoptosis at a distal signalling step.

Authors:  D E Macfarlane; L Manzel; A M Krieg
Journal:  Immunology       Date:  1997-08       Impact factor: 7.397

Review 6.  DNA and RNA-based vaccines: principles, progress and prospects.

Authors:  W W Leitner; H Ying; N P Restifo
Journal:  Vaccine       Date:  1999-12-10       Impact factor: 3.641

Review 7.  The promise of nucleic acid vaccines.

Authors:  N P Restifo; H Ying; L Hwang; W W Leitner
Journal:  Gene Ther       Date:  2000-01       Impact factor: 5.250

Review 8.  Traditional biochemical assays for studying toll-like receptor 9.

Authors:  Cynthia A Leifer; William A Rose; Fernando Botelho
Journal:  J Immunoassay Immunochem       Date:  2013

9.  Multiple effects of codon usage optimization on expression and immunogenicity of DNA candidate vaccines encoding the human immunodeficiency virus type 1 Gag protein.

Authors:  L Deml; A Bojak; S Steck; M Graf; J Wild; R Schirmbeck; H Wolf; R Wagner
Journal:  J Virol       Date:  2001-11       Impact factor: 5.103

10.  Antibody Opsonization of a TLR9 Agonist-Containing Virus-like Particle Enhances In Situ Immunization.

Authors:  Caitlin D Lemke-Miltner; Sue E Blackwell; Chaobo Yin; Anna E Krug; Aaron J Morris; Arthur M Krieg; George J Weiner
Journal:  J Immunol       Date:  2020-01-17       Impact factor: 5.422
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